| Cat. No. |
Product Name |
Information |
| PC-24655 |
AB521
HIF-2α inhibitor
|
AB521 (Casdatifan) is a potent, allosteric small molecule inhibitor of protumourigenic HIF-2α, potently and selectively inhibits HIF-2α-mediated transcription with IC50 of 28.9 nM in 786-O ccRCC cells (VEGF secretion inhibition). |
| PC-23633 |
ISM012-042
HIF-PHD inhibitor
|
ISM012-042 is a potent, orally gut-restricted, selective PHD1 and PHD2 inhibitor with IC50 of 1.9 nM and 2.5 nM for PHD1 hydroxylase and PHD2 hydroxylase, respectively. |
| PC-22692 |
HIF-PH inhibitor DMOG
HIF-PH inhibitor
|
DMOG (Dimethyloxallyl Glycine) is a cell permeable and competitive inhibitor of HIF prolyl hydroxylase (HIF-PH), induces HIF-1α stabilisation and accmulation in vitro and in vivo. |
| PC-21420 |
MO-2097
hnRNPA2B1 inhibitor
|
MO-2097 is a small molecule hnRNPA2B1-binding compound (ITC KD=43.1 uM) that suppresses hnRNPA2B1-induced HIF-1α protein expression under hypoxic and mimetic hypoxia. |
| PC-20456 |
ER-400583-00
HIF-1α inhibitor
|
ER-400583-00 is a small-molecule HIF-1α inhibitor, inhibits the induction of HIF-1 reporter activity in response to hypoxia with IC50 of 7.9 nM. |
| PC-20172 |
BAY 87-2243
HIF-1 inhibitor
|
BAY 87-2243 (BAY87-2243) is a highly potent, selective inhibitor of hypoxia-induced gene activation (IC50=0.7 nM), directly inhibits mitochondrial complex I. |
| PC-49790 |
GSK1120360A
HIF-PHD inhibitor
|
GSK1120360A (GSK360A) is a potent, specific and orally active inhibitor of HIF PHD enzyme with pIC50 of 8.0/7.0/6.9 for PHD1/2/3, respectively. |
| PC-49374 |
ISCA2 inhibitor 25
ISCA2 inhibitor
|
ISCA2 inhibitor 25 is a selective, orally available small molecule inhibitor of HIF-2α with IC50 of 0.92 uM, decrease HIF-1/2α levels and induce ferroptosis by targeting Iron Sulfur Cluster Assembly 2 (ISCA2), a component of the late mitochondrial Iron Sulfur Cluster (L-ISC) assembly complex. |
| PC-72737 |
Belzutifan
HIF2α inhibitor
|
Belzutifan (PT2977, MK-6482) is a potent and selective small-molecule inhibitor of HIF2α with SPA IC50 of 9 nM, EC50 of 11 nM (HIF-2α luciferase assay). |
| PC-72705 |
KUSC-5037
HIF-1 inhibitor
|
KUSC-5037 (KUSC5037) is a novel effective HIF-1 inhibitor with IC50 of 1.2 uM against HIF-1 transcriptional activity. |
| PC-72532 |
YQ-0629
HIF-2α inhibitor
|
YQ-0629 is a specific HIF-2α inhibitor, binds to HIF-2α PAS-B domain with Kd of 57.5 uM. |
| PC-72330 |
HIF inhibitor 208
HIF inhibitor
|
HIF inhibitor 208 is a small molecule inhibitor of HIF pathway with IC50 of 0.5 nM. |
