| Cat. No. |
Product Name |
Information |
| PC-38154 |
S1g-2
Hsp70-Bim inhibitor
|
S1g-2 (Hsp70-Bim inhibitor S1g-2) is a selective inhibitor to block interactions of Hsp70-Bim with IC50 of 0.4 uM in FPA assays, > 40-fold selectivity to target Hsp70-Bim over Bcl-2-Bim. |
| PC-38121 |
Gamitrinib TPP hexafluorophosphate
HSP90 inhibitor
|
Gamitrinib is a small molecule mitochondrial Hsp90 inhibitor, selectively targets Hsp90 network in tumor mitochondria. |
| PC-35998 |
YZ129
HSP90 inhibitor, NFAT inhibitor
|
YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM. |
| PC-35390 |
JG-231
Hsp70-BAG3 inhibitor
|
JG-231 is an allosteric inhibitor that disrupts the Hsp70-BAG3 interaction (Ki=0.11 uM), inhibits breast cancer cells MCF-7 and MDA-MB-231 with IC50 of 0.12 and 0.25 uM, respectively. |
| PC-35293 |
KBU2046
CDC37/HSP90β inhibitor
|
KBU2046 (KBU-2046) is a highly selective inhibitor of metastasis, binds to and stabilizes CDC37/HSP90β heterocomplexes. |
| PC-35115 |
SNX-9114
HSP90 inhibitor
|
SNX-9114 (SNX9114, PF-04944733) is a small molecule Hsp90 inhibitor with excellent brain permeability. |
| PC-63505 |
Aminoxyrone
HSP90 inhibitor
|
Aminoxyrone (AX) is a novel peptidometic C-terminal HSP90 inhibitor by targeting HSP90 dimerization via the C-terminal domain (CTD) with Kd of 27.4 uM. |
| PC-63360 |
ITZ-1
HSP90 inhibitor
|
ITZ-1 is a client-selective Hsp90 inhibitor that efficiently induces heat shock factor 1 (HSF1) activation, selectively inhibits IL-1β-induced MMP-13 production (IC50=0.51 uM) via inhibition of ERK activation. |
| PC-43120 |
HSP70-IN-27c
Hsp70 inhibitor
|
HSP70-IN-27c is a potent, irreversible inhibitor of Hsp70 without Hsp 90 binding activity, inhibits growth of Kasumi-1 AML cells with IC50 of 2.3 uM, and inhibits Caspase-3,7 activation in MOLM13 AML cells with IC50 of 1.9 uM. |
| PC-63191 |
HSP27 inhibitor J2
HSP27 inhibitor
|
HSP27 inhibitor J2 is a small molecule functional inhibitor of Hsp27, induces significant abnormal HSP27 dimer formation in cancer cells. |
| PC-62650 |
HS-72
Hsp70i inhibitor
|
HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome. |
| PC-62622 |
Col003
HSP47-collagen inhibitor
|
Col003 is a small-molecule compound that inhibits the interaction of Hsp47 with collagen with IC50 of 1.8 uM, binds to the collagen-binding site on Hsp47. |
