| Cat. No. |
Product Name |
Information |
| PC-62492 |
JG-98
Hsp70 inhibitor
|
JG-98 is an allosteric Hsp70 inhibitor, displays >3-fold more active, greater stability than MKT-077 against the breast cancer cell lines MDA-MB-231 and MCF-7 (EC50 of 0.4 uM and 0.7 uM, respectively). |
| PC-62491 |
SNX-2112
HSP90 inhibitor
|
SNX-2112 (PF-04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β. |
| PC-62469 |
Hsp70 inhibitor YK5
Hsp70 inhibitor
|
YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells. |
| PC-62353 |
HSP70 modulator 115-7c
Hsp70 modulator
|
HSP70 modulator 115-7c is an artificial co-chaperone, enhancer of Hsp70, stimulats the ATPase and protein-folding activities of a prokaryotic Hsp70 (DnaK) and partially compensated for a Hsp40 loss-of-function mutation in yeast. |
| PC-62335 |
ACO1
Grp94 inhibitor
|
ACO1 is a potent, selective Grp94 inhibitor with IC50 of 0.44 uM, displays >200-fold selectivity against other Hsp90 isoforms. |
| PC-62198 |
YM-1
Hsp70 inhibitor
|
YM-1 is a close derivative of MTK-077 that allosterically promotes Hsp70 binding to unfolded substrates, specificly binds to Hsp70 with Kd of 4.9 uM. |
| PC-61958 |
TAS-116
HSP90α/β inhibitor
|
TAS-116 (Pimitespib, TAS116) is a novel potent, selective, orally available HSP90α/β inhibitor with Ki of 34.7, 21.3, >50,000, and >50,000 nM for HSP90α, HSP90β, GRP94, and TRAP1, respectively. |
| PC-61797 |
NSC 145366
HSP90 inhibitor
|
NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM. |
| PC-61633 |
CCT018159
DDX39B inhibitor, Hsp90 inhibitor
|
CCT018159 is al potent inhibitor of Hsp90 ATPase activity with IC50 of 7.1 uM, also inhibits the ATPase activity of R-loop unwinding helicase DDX39B (UAP56). |
| PC-61302 |
HSF1A
HSF1 activator
|
HSF1A is a small molecule human HSF1 (heat shock transcription factor 1) activator, also interacts with components of the TRiC/CCT complex. |
| PC-61250 |
KW-2478
HSP90 inhibitor
|
KW-2478 (KW2478) is a novel potent Hsp90 inhibitor with IC50 of 3.8 nM (Hsp90α), exhibits antitumor activities both in vitro and in vivo. |
| PC-70363 |
Hsp90α inhibitor A17
Hsp90α/p23 inhibitor
|
Hsp90α inhibitor A17 is a potent Hsp90α/p23 interaction inhibitor with IC50 of 0.15 uM, more effective than CP-9 in degrading pAkt/total Akt and Raf-1. |
