| Cat. No. |
Product Name |
Information |
| PC-38671 |
Pulrodemstat
LSD1 inhibitor
|
Pulrodemstat (CC-90011) is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with biochemical IC50 of 0.3 nM. |
| PC-38508 |
GSK-J1
KDM6A/6B inhibitor
|
GSK-J1 is a potent, selective inhibitor of the H3K27 histone demethylases JMJD3 (KDM6B) and UTX (KDM6A) with IC50 of 28 nM and 53 nM, respectively. |
| PC-72834 |
JIB-04
Jumonji KDM inhibitor
|
JIB-04 is a pan-Jumonji histone demethylase inhibitor (IC50=230-1100 nM) with epigenetic activity, also potently inhibits SARS-CoV-2 replication in Vero E6 cells with EC50 of 695 nM. |
| PC-72453 |
KDOBA67
KDM6A/B inhibitor
|
KDOBA67 is a novel cell-permeable inhibitor of H3K27 lysine demethylase KDM6A/B, inhibits TBXT expression chordoma cell lines. |
| PC-72386 |
MO-I-500
FTO inhibitor
|
MO-I-500 is a pharmacological inhibitor of FTO, inhibits purified FTO demethylase catalyzing demethylation with IC50 of 8.7 uM. |
| PC-72385 |
FTO inhibitor CS1
FTO inhibitor
|
FTO inhibitor CS1 (Bisantrene, NSC 337766) is a potent, selective small-molecule inhibitor of m6A demethylase FTO, inhibits m6A demethylation with IC50 of 142.6 nM in vitro (cell-free) assays. |
| PC-72265 |
SKLB325
JMJD6 inhibitor
|
SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM. |
| PC-72264 |
JMJD7 inhibitor compound 3 (Cpd-3)
JMJD7 inhibitor
|
JMJD7 inhibitor compound 3 (Cpd-3) is the first small molecule inhibitor of JMJD7 with IC50 of 6.62 uM, efficiently bind to JMJD7 in vitro, displays good inhibitory activity against cancer cell lines expressing a high level of JMJD7. |
| PC-72263 |
MINA53 inhibitor 10
MINA53 inhibitor
|
MINA53 inhibitor 10 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.5 uM, selective over NO66, KDM4-6 and other JmjC oxygenases. |
| PC-72262 |
MINA53 inhibitor 9
MINA53 inhibitor
|
MINA53 inhibitor 9 is a first in class, potent, selective MINA53 inhibitor with IC50 of 1.6 uM, selective over NO66, KDM4-6 and other JmjC oxygenases. |
| PC-72259 |
TACH101
KDM4 inhibitor
|
TACH101 (Zavondemstat, QC8222, TACH 101) is a reversible, α-ketoglutarate competitive, selective and potent inhibitor of KDM4 isoforms A-D with IC50 values of 80 nM against all four isoforms. |
| PC-72226 |
FTO-04
FTO inhibitor
|
FTO-04 is a potent, selective, competitive small molecule inhibitor of m6A-RNA demethylase FTO with IC50 of 3.39 uM, 13-fold selectivity over RNA demethylase ALKBH5 (ALKBH5, IC50=39.4 uM). |
