| Cat. No. |
Product Name |
Information |
| PC-62430 |
AI-2
Nrf2 activator
|
Nrf2 activator AI-2 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1. |
| PC-62429 |
AI-1
Nrf2 activator
|
Nrf2 activator AI-1 is a small-molecule inducer of the antioxidant response element (ARE) that activates and stabilizes Nrf2 by covalently modifying Keap1, activates an ARE-dependent luciferase reporter with an EC50 of 2.7 uM. |
| PC-62392 |
AEM1
Nrf2 inhibitor
|
NRF2 inhibitor AEM1 is a specific small molecule inhibitor of Nrf2 transcriptional activity in cancer cells, shows no activity against a panel of >100 kinases (including isoforms of PI3K, AKT, and PKC). |
| PC-70279 |
MIND4-17
Nrf2 activator
|
MIND4-17 is an inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM. |
| PC-60016 |
BPK-29
NR0B1 inhibitor
|
BPK-29 (BPK29) is a covalent, specific small molecule that disrupts NR0B1 protein complexes and impairs the anchorage-independent growth of KEAP1-mutant cancer cells. |
| PC-42916 |
RTA-408
Nrf2 activator
|
RTA-408 (Omaveloxolone, RTA408) is a potent Nrf2 activator that increases expression of Nrf2 target genes and decreases expression of inflammatory mediators. |
| PC-45198 |
Ezetimibe
Nrf2 activator, NPC1L1 inhibitor
|
Ezetimibe is a potent Niemann-Pick C1-Like 1 (NPC1L1) cholesterol absorption receptor inhibitor that inhibits sterol absorption without affecting the absorption of other molecules. |
| PC-42187 |
ML-385
Nrf2 inhibitor
|
ML 385 is a first-in-class small molecule inhibitor of NRF2 that binds to Neh1 DNA binding domain of NRF2 (IC50=1.9 uM) and inhibits the downstream target gene expression. |
| PC-21180 |
NRF2 inhibitor R16
NRF2 inhibitor
|
NRF2 inhibitor R16 is a novel mutated KEAP1 (mKEAP1)-selective NRF2 inhibitor, binds KEAP1-mutated proteins (G333C mKEAP1, Kd=2.7 uM) and restores their interaction with NRF2, leading to proteasome-dependent NRF2 degradation. |
| PC-21171 |
Spinosin
Nrf2/HO-1 activator
|
Spinosyn is a C-glycoside flavonoid isolated from the seeds of Zizyphus jujube with neuroprotective effects, inhibits Aβ1-42 production and aggregation via activating Nrf2/HO-1 pathway. |
| PC-20849 |
sAKZ692
NRF2 activator
|
sAKZ692 (sAKZ-692) is a small molecule activator of NRF2 transcriptional activity (EC50=2.2 uM) in cells by inhibiting the glycolytic enzyme pyruvate kinase. |
| PC-20558 |
Keap1-Nrf2 inhibitor 25
Keap1-Nrf2 inhibitor
|
Keap1-Nrf2 inhibitor 25 is a potent, orally bioavailable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor with IC50 of 89 nM. |
