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Cat. No. Product Name Information
PC-20026

HRX215

MKK4 inhibitor

Darizmetinib (HRX215, HRX0215) is a first-in-class, potent, selective inhibitor of MKK4 (mitogen-activated protein kinase kinase 4, MEK4, MAP2K4) with IC50 of 20 nM, >100-fold selectivity against JNK1, BRAF, and MKK7.
PC-72995

URML-3881

MEK inhibitor

URML-3881 (URML3881) is a potent, specific MEK1/2 inhibitor IC50 of 30 nM in a cell-free kinase inhibition assay.
PC-72697

MAP855

MEK1/2 inhibitor

MAP855 (MAP-855) is a highly potent, selective, ATP-competitive MEK1/2 inhibitor (pERK IC50=5 nM) with equipotent inhibition of WT and mutant MEK1/2.
PC-72696

DTP3

MKK7 inhibitor

DTP3 (MKK7 inhibitor DTP3) is a specific D-tripeptide that disrupts the GADD45β/MKK7 complex (Kd=64.8 nM), kills MM cells effectively, and lacks toxicity to normal cells.
PC-72695

MEK4 inhibitor 6ff

MEK4 inhibitor

MEK4 inhibitor 6ff is potent, selective MEK4 inhibitor with IC50 of 66 nM.
PC-72692

MEK4 inhibitor 15o

MEK4 inhibitor

MEK4 inhibitor 15o is potent, selective, cell permeable MEK4 inhibitor with IC50 of 83 nM.
PC-72689

MEK4 inhibitor 10e

MEK4 inhibitor

MEK4 inhibitor 10e is potent, selective cell permeable MEK4 inhibitor with IC50 of 61 nM.
PC-38277

BSJ-04-122

MKK4/7 inhibitor

BSJ-04-122 is a potent, selective, covalent dual MKK4/7 inhibitor with IC50 of 4/181 nM, displays excellent kinome selectivity.
PC-36064

MMK7 inhibitor 4a

MKK7 inhibitor

MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7 with IC50 of 10 nM, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M.
PC-35805

MKK7-COV-9

MKK7 inhibitor

MKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor, displays >1,000-fold selectivity over MKK4.
PC-35804

MKK7-COV-13

MKK7 inhibitor

MKK7-COV-13 (MKK7 Covalent inhibitor 13) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 10 nM, displays >1,000-fold selectivity over MKK4 (IC50>10 uM).
PC-35803

MKK7-COV-3

MKK7 inhibitor

MKK7-COV-3 (MKK7 Covalent inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM, displays >1,000-fold selectivity over MKK4 (IC50=7.81 uM).

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