Cat. No. |
Product Name |
Information |
PC-20026 |
HRX215
MKK4 inhibitor
|
Darizmetinib (HRX215, HRX0215) is a first-in-class, potent, selective inhibitor of MKK4 (mitogen-activated protein kinase kinase 4, MEK4, MAP2K4) with IC50 of 20 nM, >100-fold selectivity against JNK1, BRAF, and MKK7. |
PC-72995 |
URML-3881
MEK inhibitor
|
URML-3881 (URML3881) is a potent, specific MEK1/2 inhibitor IC50 of 30 nM in a cell-free kinase inhibition assay. |
PC-72697 |
MAP855
MEK1/2 inhibitor
|
MAP855 (MAP-855) is a highly potent, selective, ATP-competitive MEK1/2 inhibitor (pERK IC50=5 nM) with equipotent inhibition of WT and mutant MEK1/2. |
PC-72696 |
DTP3
MKK7 inhibitor
|
DTP3 (MKK7 inhibitor DTP3) is a specific D-tripeptide that disrupts the GADD45β/MKK7 complex (Kd=64.8 nM), kills MM cells effectively, and lacks toxicity to normal cells. |
PC-72695 |
MEK4 inhibitor 6ff
MEK4 inhibitor
|
MEK4 inhibitor 6ff is potent, selective MEK4 inhibitor with IC50 of 66 nM. |
PC-72692 |
MEK4 inhibitor 15o
MEK4 inhibitor
|
MEK4 inhibitor 15o is potent, selective, cell permeable MEK4 inhibitor with IC50 of 83 nM. |
PC-72689 |
MEK4 inhibitor 10e
MEK4 inhibitor
|
MEK4 inhibitor 10e is potent, selective cell permeable MEK4 inhibitor with IC50 of 61 nM. |
PC-38277 |
BSJ-04-122
MKK4/7 inhibitor
|
BSJ-04-122 is a potent, selective, covalent dual MKK4/7 inhibitor with IC50 of 4/181 nM, displays excellent kinome selectivity. |
PC-36064 |
MMK7 inhibitor 4a
MKK7 inhibitor
|
MMK7 inhibitor 4a is a potent, sepecific, covalent inhibitor of MMK7 with IC50 of 10 nM, displays >800-fold selectivity over EGFR-WT and EGFR-L858R/T790M. |
PC-35805 |
MKK7-COV-9
MKK7 inhibitor
|
MKK7-COV-9 (MKK7 Covalen inhibitor 9) is a potent, selective, covalent MKK7 inhibitor, displays >1,000-fold selectivity over MKK4. |
PC-35804 |
MKK7-COV-13
MKK7 inhibitor
|
MKK7-COV-13 (MKK7 Covalent inhibitor 13) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 10 nM, displays >1,000-fold selectivity over MKK4 (IC50>10 uM). |
PC-35803 |
MKK7-COV-3
MKK7 inhibitor
|
MKK7-COV-3 (MKK7 Covalent inhibitor 3) is a potent, selective, covalent MKK7 inhibitor with in vitro IC50 of 5 nM, displays >1,000-fold selectivity over MKK4 (IC50=7.81 uM). |