| Cat. No. |
Product Name |
Information |
| PC-20303 |
JC124
NLRP3 inhibitor
|
JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells. |
| PC-20225 |
JC2-11
Inflammasome inhibitor
|
JC2-11 is an anti-inflammasome compound and a pan-inhibitor of the NLRP3, NLRC4, and AIM2 inflammasomes. |
| PC-49812 |
ML146
NOD1 inhibitor
|
ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells. |
| PC-49811 |
GSK223
NOD1 inhibitor
|
GSK223 (GSK-223) is a specific small molecule inhibitor of the NOD1 signaling pathway, shows NOD1 inhibitory activity with IC50 of 1 uM in 293/hNOD1 cell assays, does not inhibit RIP2 kinase. |
| PC-49809 |
FK 156
NOD1 agonist
|
FK156 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| PC-49463 |
NIC7
NLRP3 inhibitor
|
NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase. |
| PC-49268 |
NDT-30805
NLRP3 inhibitor
|
NDT-30805 is a potent and selective small molecule NLRP3 inflammasome inhibitor with IC50 of 13 nM for IL-1β inhibition in PBMCs. |
| PC-38557 |
GSK717
NOD2 inhibitor
|
GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, has an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
| PC-73216 |
NLRP3-IN-3
NLRP3 inhibitor
|
NLRP3-IN-3 is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of 1.26 nM in THP1 cells, showing good pharmacokinetic profiles with oral bioavailability. |
| PC-35385 |
INF39
|
INF39 (NLRP3 inhibitor INF39) is a nontoxic, irreversible, orally available NLRP3 inhibitor that inhibits NLRP3 ATPase and decreases interleukin-1β release from macrophages. |
| PC-63450 |
NBC19
|
NBC19 is a potent inhibitor of NLRP3 inflammasome, inhibits nigericin-induced ASC speck formation in post-differentiated THP1 cells with IC50 of 60 nM.. |
| PC-61787 |
JC-171
|
JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM. |
