| Cat. No. |
Product Name |
Information |
| PC-21637 |
ZYIL1
NLRP3 inhibitor
|
ZYIL1 (Usnoflast) is a potent, orally active, selective NLRP3 inflammasome inhibitor, Nigericin-mediated interleukin (IL)-1β release in isolated microglia cells with IC50 of 43 nM. |
| PC-21283 |
NT-0796
NLRP3 inhibitor
|
Ruvonoflast (NT-0796) is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM. |
| PC-21282 |
DFV890
NLRP3 inhibitor
|
DFV890 (NVP-DFV890, IFM-2427) is a potent, selective and orally active inhibitor of NLRP3 inflammasome, directly binds to NLRP3 and locks the protein in an inactive conformation, prevents NLRP3 inflammasome assembly in response to sterile danger signals. |
| PC-20956 |
ADS032
NLRP1/NLRP3 inhibitor
|
ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin‐induced NLRP3‐induced IL‐1β secretion from LPS‐primed iBMDMs with IC50 of 30 uM. |
| PC-20303 |
JC124
NLRP3 inhibitor
|
JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells. |
| PC-20225 |
JC2-11
Inflammasome inhibitor
|
JC2-11 is an anti-inflammasome compound and a pan-inhibitor of the NLRP3, NLRC4, and AIM2 inflammasomes. |
| PC-49812 |
ML146
NOD1 inhibitor
|
ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells. |
| PC-49811 |
GSK223
NOD1 inhibitor
|
GSK223 (GSK-223) is a specific small molecule inhibitor of the NOD1 signaling pathway, shows NOD1 inhibitory activity with IC50 of 1 uM in 293/hNOD1 cell assays, does not inhibit RIP2 kinase. |
| PC-49809 |
FK 156
NOD1 agonist
|
FK156 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| PC-49808 |
FK 565
NOD1 agonist
|
FK565 is an immunoactive peptide and a nucleotide-binding oligomerization domain (Nod)-1 ligand agonist. |
| PC-49463 |
NIC7
NLRP3 inhibitor
|
NLRP3-inhibitory compound 7 (NIC7) is a small-molecule inhibitor of Nod-like receptor family pyrin domain-containing 3 (NLRP3), inhibits NLRP3-mediated activation of caspase 1 along with the secretion of IL-1β, IL-18, and lactate dehydrogenase. |
| PC-49396 |
GDC-2394
NLRP3 inhibitor
|
GDC-2394 (GDC2394) is a potent and selective NLRP3 inhibitor with IC50 of 5.4 nM (IL-1β inhibition in PBMCs). |
