| Cat. No. |
Product Name |
Information |
| PC-25790 |
NP3-742
NLRP3 inhibitor
|
NP3-742 is a potent, selective NLRP3 inhibitor, inhibits IL-1β release in supernatant of nigericin stimulated THP-1 cells with IC50 of 6 nM. |
| PC-25673 |
LMT2368
NLRP3 inhibitor
|
LMT2368 is a small molecule urea-based NLRP3 inhibitor, binds to NLRP3 NACHT domain with KD of 27.4 uM, dose-dependently suppresses IL-1β secretion (IC50=0.8 μM in J774A.1 cells) and caspase-1 activation without affecting NF-κB signaling. |
| PC-25503 |
NT-0249 free base
NLRP3 inhibitor
|
NT-0249 free base is a potent, specific NLRP3 inhibitor, potently inhibits palmitate-driven IL-1β release from human PBMCs with IC50 of 11 nM. |
| PC-25502 |
NT-0527
NLRP3 inhibitor
|
NT-0527 is a highly potent, selective and brain penetrant and orally bioavailable NLRP3 inflammasome inhibitor, inhibits NLRP3 inflammasome-mediated IL-1β production triggered by multiple second stimuli (ATP, IC50=87 nM; CPPD, IC50=40 nM). |
| PC-25460 |
BAL-0598
NLRP3 inhibitor
|
BAL-0598 is a potent and selective, non-covalent inhibitor of human NLRP3, binds NLRP3 NACHT with a steady-state KD of 193 nM in SPR assays. |
| PC-25092 |
Sebrinoflast
NLRP3 inhibitor
|
Sebrinoflast is a potent, selective NLRP3 inhibitor. |
| PC-24847 |
GDC-2394 sodium salt
NLRP3 inhibitor
|
GDC-2394 sodium salt (GDC2394) is a potent and selective NLRP3 inhibitor with IC50 of 5.4 nM (IL-1β inhibition in PBMCs). |
| PC-24562 |
VEN-02XX
NLRP3 inhibitor
|
VEN-02XX is a a novel potent and selective brain-penetrant small molecule NLRP3 inhibitor with binding KD of 93.3 nM, inhibits IL-1β production in PBMCs with IC50 of 0.35 uM. |
| PC-24509 |
OLT1177
NLRP3 inhibitor
|
OLT1177 (Dapansutrile) is an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome, prevents NLRP3-ASC, as well as NLRP3-caspase-1 interaction, thus inhibiting NLRP3 inflammasome oligomerization. |
| PC-23679 |
ASP0965
NLRP3 inhibitor
|
ASP0965 is potent, orally active and brain-penetrable NLRP3 inflammasome inhibitor with IC50 of 8.4 nM (in vitro IL-1β inhibitory activity). |
| PC-23602 |
NOD1 antagonist 66
NOD1 inhibitor
|
NOD1 antagonist 66 is a potent and selective antagonist of both human and mouse NOD1, inhibits h/mNOD1-induced NF-κB activation in HEK293 cells with IC50 of 0.8 nM and 32 nM respectively. |
| PC-23598 |
NLRP3 inhibitor compound A
NLRP3 inhibitor
|
NLRP3 inhibitor compound A is a potent, highly selective NLRP3 inflammasome inhibitor with IC50 of 67 nM for inhibition of IL-1β in PBMCs, targets ATPase activity of NLRP3 through binding to Walker A motif. |
