| Cat. No. |
Product Name |
Information |
| PC-25092 |
Sebrinoflast
NLRP3 inhibitor
|
Sebrinoflast is a potent, selective NLRP3 inhibitor. |
| PC-24847 |
GDC-2394 sodium salt
NLRP3 inhibitor
|
GDC-2394 sodium salt (GDC2394) is a potent and selective NLRP3 inhibitor with IC50 of 5.4 nM (IL-1β inhibition in PBMCs). |
| PC-24562 |
VEN-02XX
NLRP3 inhibitor
|
VEN-02XX is a a novel potent and selective brain-penetrant small molecule NLRP3 inhibitor with binding KD of 93.3 nM, inhibits IL-1β production in PBMCs with IC50 of 0.35 uM. |
| PC-24509 |
OLT1177
NLRP3 inhibitor
|
OLT1177 (Dapansutrile) is an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome, prevents NLRP3-ASC, as well as NLRP3-caspase-1 interaction, thus inhibiting NLRP3 inflammasome oligomerization. |
| PC-23679 |
ASP0965
NLRP3 inhibitor
|
ASP0965 is potent, orally active and brain-penetrable NLRP3 inflammasome inhibitor with IC50 of 8.4 nM (in vitro IL-1β inhibitory activity). |
| PC-23602 |
NOD1 antagonist 66
NOD1 inhibitor
|
NOD1 antagonist 66 is a potent and selective antagonist of both human and mouse NOD1, inhibits h/mNOD1-induced NF-κB activation in HEK293 cells with IC50 of 0.8 nM and 32 nM respectively. |
| PC-23598 |
NLRP3 inhibitor compound A
NLRP3 inhibitor
|
NLRP3 inhibitor compound A is a potent, highly selective NLRP3 inflammasome inhibitor with IC50 of 67 nM for inhibition of IL-1β in PBMCs, targets ATPase activity of NLRP3 through binding to Walker A motif. |
| PC-23493 |
NP3-253
NLRP3 inhibitor
|
NP3-253 is a potent, selective and brain penetrant inhibitor of the NLRP3 inflammasome, inhibits IL-1β release in nigericin-stimulated THP-1 cells with IC50 of 0.5 nM. |
| PC-23200 |
YM-I-26
NLRP3 inhibitor
|
YM-I-26 is a highly selective NLRP3 inflammasome inhibitor, binds to recombinant NLRP3 with Kd of 560.2 nM. |
| PC-22764 |
INF200
NLRP3 inhibitor
|
INF200 is a novel sulfonylurea-based NLRP3 inhibitor, specifically inhibits NLRP3-driven pyroptosis with IC50 of 1.55 uM, efficiently reduces cardiac and metabolic complications in in vivo model of diet-induced metaflammation. |
| PC-22763 |
INF195
NLRP3 inhibitor
|
INF195 is a small molecule NLRP3 inhibitor, specifically inhibits NLRP3-driven pyroptosis and IL-1 β release in human macrophages. |
| PC-22042 |
NLRP3 inhibitor NIC-11
NLRP3 inhibitor
|
NIC-11 is a highly potent broad-spectrum NLRP3 inhibitor, inhibits NLRP3 inflammasome activation (IL-1β release) in mouse macrophages with IC50 of 69 nM. |
