| Cat. No. |
Product Name |
Information |
| PC-61787 |
JC-171
NLRP3 inhibitor
|
JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM. |
| PC-42228 |
NOD-IN-1
NOD1/NOD2 inhibitor
|
NOD-IN-1 is a potent, dual inhibitor of NOD1 and NOD2 with IC50 of 5.74 uM and 6.45 uM, respectively. |
| PC-45499 |
Nodinitib-1
NOD1 inhibitor
|
Nodinitib-1 (ML130, Noditinib 1) is a potent and selective NOD1 inhibitor with IC50 of 0.56 uM. |
| PC-27694 |
VVD-338213
NLRP3 inhibitor
|
VVD-338213 is a potent, brain-penetrant, covalent NLRP3 inhibitor with IC50 of 89 nM for inhibiton of IL-1β secretion from human PBMCs, inhibits IL-1β release via preventing inflammasome formation. |
| PC-27509 |
Trabzanoflast
NLRP3 inhibitor
|
Trabzanoflast is a potent, selective NLRP3 inflammasome inhibitor. |
| PC-27416 |
Clasornoflast
NLRP3 inhibitor
|
Clasornoflast is a potent, selective NLRP3 inflammasome inhibitor. |
| PC-27383 |
KBD3536
NLRP3 inhibitor
|
KBD3536 is a potent small-molecule NLRP3 inhibitor with IC50 of 27.7 nM in the THP-1 pyroptosis assays, IC50 of 19.5 nM for inhibition of IL-1β secretion in LPS- and ATP-stimulated PBMCs. |
| PC-26289 |
Isolinderalactone
TNF-α/STAT3 inhibitor, NLRP3 inhibitor
|
Isolinderalactone is a sesquiterpene compound derived from the Lindera aggregata root with significant anti-inflammatory and anti-cancer effects, inhibits TNF-α/STAT3 inflammatory pathways, dose-dependently suppresses IL-1β secretion through inhibiting NLRP3 inflammasome activation with IC50 of 2.88 uM, alleviates atherosclerosis by inhibiting NLRP3 inflammasome activation and inflammatory response in macrophages. |
| PC-26153 |
Abdenoflast
NLRP3 inhibitor
|
Abdenoflast is a potent selective and non-steroidal NLRP3 inflammasome inhibitor with anti-inflammatory activity. |
| PC-25790 |
NP3-742
NLRP3 inhibitor
|
NP3-742 is a potent, selective NLRP3 inhibitor, inhibits IL-1β release in supernatant of nigericin stimulated THP-1 cells with IC50 of 6 nM. |
| PC-25673 |
LMT2368
NLRP3 inhibitor
|
LMT2368 is a small molecule urea-based NLRP3 inhibitor, binds to NLRP3 NACHT domain with KD of 27.4 uM, dose-dependently suppresses IL-1β secretion (IC50=0.8 μM in J774A.1 cells) and caspase-1 activation without affecting NF-κB signaling. |
| PC-25502 |
NT-0527
NLRP3 inhibitor
|
NT-0527 is a highly potent, selective and brain penetrant and orally bioavailable NLRP3 inflammasome inhibitor, inhibits NLRP3 inflammasome-mediated IL-1β production triggered by multiple second stimuli (ATP, IC50=87 nM; CPPD, IC50=40 nM). |
