| Cat. No. |
Product Name |
Information |
| PC-49610 |
Halofuginone
PfcPRS inhibitor
|
Halofuginone (RU-19110) is a small molecule febrifugine analog targeting the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS, Ki=18.3 nM), inhibits wildtype Dd2 strain of P. falciparum with EC50 of 0.5 nM. |
| PC-49609 |
Febrifugine
PfcPRS inhibitor
|
Febrifugine is a quinazolinone alkaloid for treating malaria-induced fever for about 2000 years, targets the Plasmodium falciparum prolyl-tRNA synthetase (PfcPRS). |
| PC-49605 |
SCR0911
Cyt bc inhibitor
|
SCR0911 is a potent malarial cytochrome bc1 inhibitor, inhibits cell growth and ATP synthesis in both the fast- and slow-growing M. smegmatis and M. bovis bacillus Calmette-Guérin, respectively. |
| PC-49603 |
AWE402
Cyt bcc-aa3 inhibitor
|
AWE402 (AWE-402) is a small molecule inhibitor targeting M. tuberculosis cytochrome bcc-aa3 of the electron transport chain (ETC), shows MIC value of 5 nM activity against Mycobacterium tuberculosis H37Rv. |
| PC-49602 |
CK-2-63
Cyt bd inhibitor
|
CK-2-63 is a potent first-in-class M. tuberculosis cytochrome bd (cyt bd) inhibitor, demonstrates growth suppression of M. tuberculosis H37Rv with IC50 of 3.7 uM. |
| PC-49323 |
KNX-115
PfMyoA inhibitor
|
KNX-115 (KNX115) is a potent, selective inhibitor of plasmodium falciparum myosin A (PfMyoA), inhibits PfMyoA actin-activated ATPase with Ki of 17 nM, >50-fold selectivity against cardiac, skeletal, and smooth muscle myosins. |
| PC-49314 |
AN15368
Anti-parasite
|
AN15368 (AN 15368) is a small molecule prodrug activated by parasite carboxypeptidases to yield a compound that targets the messenger RNA processing pathway in Trypanosoma cruzi (T. cruzi), exhibits potent in vitro activity against T. cruzi with IC50 of 5 nM. |
| PC-49292 |
DDD01510706
PfKRS inhibitor
|
DDD01510706 is a small molecule inhibitor of PfKRS (Plasmodium falciparum Lysyl tRNA Synthetase) with pIC50 of 6.62, interacts with the ATP binding site of PfKRS, inhibits plasmodium falciparum asexual blood-stage (ABS) parasite strain Dd2 with EC50 of 0.3 uM. |
| PC-49283 |
T-3767758
ProRS inhibitor
|
T-3767758 is a potent, proline-uncompetitive inhibitor of prolyl-tRNA synthetase (ProRS), displays good activity with EC50 of 595 nM against P. falciparum Dd2-2D4 wild-type parasites. |
| PC-47070 |
NPD-001
TbrPDEB1 inhibitor
|
NPD-001 is a potent trypanosomal phosphodiesterases B1 and B2 (TbrPDEB1 and TbrPDEB2) with IC50 of 4 nM ,and 3 nM, resectively, shows in vitro trypanocidal activities. |
| PC-47035 |
UBMC-4
T. cruzi inhibitor
|
UBMC-4 is a potential Trypanosoma cruzi AKT-like pleckstrin homology (PH) domain, exhibits trypanocidal effect on T. cruzi amastigotes with EC50 of 1.85 uM (0.774 ug/mL). |
| PC-47013 |
GNF179
Antimalarial
|
GNF179 is an antimalarial imidazolopiperazine, possesses low nanomolar potency against P. falciparum liver stages, asexual blood stages and sexual stage gametocytes. |
