| Cat. No. |
Product Name |
Information |
| PC-27971 |
MMV020291
Antimalarial
|
MMV020291 (MMV291) is a specific antimalarial inhibitor of red blood cells (RBC) invasion, specifically blocks merozoite entry into RBCs, reduces actin polymerisation that is required by the merozoite stage parasites to invade RBCs. |
| PC-27967 |
Dihydroartemisinin
Antimalarial, Ferroptosis inducer
|
Dihydroartemisinin (DHA, Artenimol, β-Dihydroartemisinin) is an antimalarial agent and semi-synthetic derivative of Artemisinin, also has anti-inflammatory and anti-cancer effect, directly binds to YTHDF2 and inhibits its function, induces autophagy by inhibiting NF-κB activation, induces iron-dependent cell death (ferroptosis) in tumor cells. |
| PC-27569 |
WHZ-04
Pf20S inhibitor
|
WHZ-04 is a potent, selective P. falciparum 20S proteasome (Pf20S) inhibitor with IC50 of 20.8 nM for Pf20S β5, has 68-fold and 4.8-fold selectivity over β5c and β5i, shows antimalarial EC50 of 8.4 nM against Pf 3D7. |
| PC-27443 |
RUPB-61
PfPKG inhibitor
|
RUPB-61 is a potent, selective and orally bioavailable inhibitor of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) with IC50 of 13 nM, EC50 of 50 uM against multi-drug resistant P. falciparum lab strain 3D7, blocks sporozoite infection of the liver. |
| PC-27209 |
CWHM-1008
Antimalarial
|
CWHM-1008 is a potent, orally efficacious antimalarial agent with EC50 values of 46 nM and 21 nM against drug sensitive Plasmodium falciparum 3D7 and drug resistant Dd2 strains, respectively. |
| PC-27175 |
UCB-9721
TgMyoA inhibitor
|
UCB-9721 is a potent inhibitor of T. gondii MyoA (TgMyoA) with IC50 of 31 nM, a class XIV myosin motor of apicomplexan parasites, inhibits TgMyoA actin-activated ATPase activity. |
| PC-26662 |
DNDI-6148
Visceral leishmaniasis inhibitor
|
DNDI-6148 is a potent, selective inhibitor of Visceral leishmaniasis (VL) with EC50 of 1.8 uM and 1.4 uM for intramacrophage L. infantum and L. donovani, inhibits Leishmania cleavage and polyadenylation specificity factor (CPSF3) endonuclease. |
| PC-26128 |
Cruzidione
T. cruzi inhibitor
|
Cruzidione is a potent anti-T. cruzi activity and anti-Chagas compound with anti-trypanosomal activity with IC50 of 3.65 uM. |
| PC-25928 |
IID432
T. cruzi Topo II inhibitor
|
IID432 (IID-432) is a highly potent inhibitor of Trypanosoma cruzi topoisomerase II (T. cruzi Topo II), shows potent activity against T. cruzi with EC50 of 8 nM. |
| PC-25293 |
LXE408
Kinetoplastid proteasome inhibitor
|
Galeflaprit (LXE408) is a potent, selective inhibitor of the kinetoplastid proteasome with IC50 of 0.04 uM (L. donovani proteasome), inhibits L. donovani amastigote proliferation within primary mouse macrophages (IC50=0.04 uM). |
| PC-25200 |
BKI-1708
CpCDPK1 inhibitor
|
BKI-1708 is a highly potent, specific Cryptosporidium calcium-dependent protein kinase 1 (CDPK1) inhibitor with IC50 of 0.7 nM (CpCDPK1, C. parvum CDPK1) and EC50 of 0.4 uM against C. parvum parasites in Nanoluciferase assays. |
| PC-25005 |
ZY-19489
Antimalarial
|
Sutidiazine (Zintrodiazine, ZY-19489, MMV 253, AZ-13721412) is a novel antimalarial triaminopyrimidine compound with IC50 of 9 nM against sexual blood stage of Plasmodium falciparum (Pf). |
