Cat. No. |
Product Name |
Information |
PC-49023 |
BMS-336
RORγt inhibitor
|
BMS-336 is a potent, selective, orally active RORγt (RORC2) inverse agonist with EC50 of 39 nM in RORγt reporter assays. |
PC-38747 |
PCCR-1
RORγ inhibitor
|
PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR. |
PC-73062 |
A-9758
RORγt inhibitor
|
A-9758 (A9758) is a selective, small molecule inverse agonist of retinoid-related orphan receptor gamma t (hRORγt IC50=38 nM). |
PC-35406 |
MRL-871
RORγt inhibitor
|
MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM. |
PC-35405 |
SR2211
RORγt inhibitor
|
SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells. |
PC-35306 |
CD12681
|
CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR). |
PC-43525 |
SR1001
|
SR1001 is a higly potent, specific, inverse agonist of both RORα and RORγt with binding Ki of 172 and 111 nM, does not binds RORβ and devoid of LXR activity. |
PC-63532 |
LYC-55716
RORγ agonist
|
Cintirorgon (LYC-55716) is a potent, selective, and orally bioavailable Retinoic acid Receptor-related orphan receptor-γ (RORγ) agonist with FRET EC50 of 13 nM. |
PC-63337 |
AZD-0284
RORC2 inverse agonist
|
AZD-0284 is a potent, selective, orally bioavailable RORC2 inverse agonist with IC50 of 17 nM in TH17 cell assays. |
PC-43201 |
GSK805
RORγt inhibitor
|
GSK805 is a potent, orally bioavailable, CNS penetrant RORγt inhibitor with pIC50 of 8.5 and 8.0 in FRET and Th17 assays, respectively. |
PC-63177 |
TAK-828F
RORγt inhibitor
|
TAK-828F (TAK-828) is a potent, selective, orally available RORγt inverse agonist with binding IC50 of 1.9 nM and reporter IC50 of 6.0 nM, displays excellent selectivity (>5,000-fold) against other ROR isoforms and nuclear receptors. |
PC-60455 |
GSK 2981278
|
GSK 2981278 (GSK2981278) is a potent, highly selective RORγ/RORγt inhibitor that potently inhibits IL-17A and IL-22 protein secretion in human peripheral T cell with IC50 of 3.2 nM. |