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Cat. No. Product Name Information
PC-49023

BMS-336

RORγt inhibitor

BMS-336 is a potent, selective, orally active RORγt (RORC2) inverse agonist with EC50 of 39 nM in RORγt reporter assays.
PC-38747

PCCR-1

RORγ inhibitor

PCCR-1 is a potent, specific RORγ inhibitor with binding IC50 of 34.45 nM and 778.1 nM for human and mouse RORγ, respectively, > 300-fold selectivity over other isoforms of ROR.
PC-73062

A-9758

RORγt inhibitor

A-9758 (A9758) is a selective, small molecule inverse agonist of retinoid-related orphan receptor gamma t (hRORγt IC50=38 nM).
PC-35406

MRL-871

RORγt inhibitor

MRL-871 (MRL871) is a potent, selective inhibitor of RORγt via allosteric inverse agonism, inhibits coactivator binding with IC50 of 7 nM.
PC-35405

SR2211

RORγt inhibitor

SR2211 (SR-2211) is a potent, selective RORγ inverse agonist (Ki=105 nM, IC50=320 nM) that potently inhibits production of IL-17 in cells.
PC-35306

CD12681

CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR).
PC-43525

SR1001

SR1001 is a higly potent, specific, inverse agonist of both RORα and RORγt with binding Ki of 172 and 111 nM, does not binds RORβ and devoid of LXR activity.
PC-63532

LYC-55716

RORγ agonist

Cintirorgon (LYC-55716) is a potent, selective, and orally bioavailable Retinoic acid Receptor-related orphan receptor-γ (RORγ) agonist with FRET EC50 of 13 nM.
PC-63337

AZD-0284

RORC2 inverse agonist

AZD-0284 is a potent, selective, orally bioavailable RORC2 inverse agonist with IC50 of 17 nM in TH17 cell assays.
PC-43201

GSK805

RORγt inhibitor

GSK805 is a potent, orally bioavailable, CNS penetrant RORγt inhibitor with pIC50 of 8.5 and 8.0 in FRET and Th17 assays, respectively.
PC-63177

TAK-828F

RORγt inhibitor

TAK-828F (TAK-828) is a potent, selective, orally available RORγt inverse agonist with binding IC50 of 1.9 nM and reporter IC50 of 6.0 nM, displays excellent selectivity (>5,000-fold) against other ROR isoforms and nuclear receptors.
PC-60455

GSK 2981278

GSK 2981278 (GSK2981278) is a potent, highly selective RORγ/RORγt inhibitor that potently inhibits IL-17A and IL-22 protein secretion in human peripheral T cell with IC50 of 3.2 nM.

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