| Cat. No. |
Product Name |
Information |
| PC-35084 |
SR1555
RORγ inverse agonist
|
SR1555 is a selective RORγ inverse agonist (IC50=1.5 uM) that suppresses T(H)17 cells and stimulates T regulatory cells. |
| PC-43525 |
SR1001
RORα/RORγt agonist
|
SR1001 is a higly potent, specific, inverse agonist of both RORα and RORγt with binding Ki of 172 and 111 nM, does not binds RORβ and devoid of LXR activity. |
| PC-63532 |
LYC-55716
RORγ agonist
|
Cintirorgon (LYC-55716) is a potent, selective, and orally bioavailable Retinoic acid Receptor-related orphan receptor-γ (RORγ) agonist with FRET EC50 of 13 nM. |
| PC-63473 |
Nobiletin
RORα/γ activator
|
Nobiletin is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment, also is a clock modulator that targets RORα/γ. |
| PC-63337 |
AZD-0284
RORC2 inverse agonist
|
AZD-0284 is a potent, selective, orally bioavailable RORC2 inverse agonist with IC50 of 17 nM in TH17 cell assays. |
| PC-43201 |
GSK805
RORγt inhibitor
|
GSK805 is a potent, orally bioavailable, CNS penetrant RORγt inhibitor with pIC50 of 8.5 and 8.0 in FRET and Th17 assays, respectively. |
| PC-63177 |
TAK-828F
RORγt inhibitor
|
TAK-828F (TAK-828) is a potent, selective, orally available RORγt inverse agonist with binding IC50 of 1.9 nM and reporter IC50 of 6.0 nM, displays excellent selectivity (>5,000-fold) against other ROR isoforms and nuclear receptors. |
| PC-60455 |
GSK 2981278
RORγ/RORγt inhibitor
|
GSK 2981278 (GSK2981278) is a potent, highly selective RORγ/RORγt inhibitor that potently inhibits IL-17A and IL-22 protein secretion in human peripheral T cell with IC50 of 3.2 nM. |
| PC-60454 |
TMP778
RORγt inhibitor
|
TMP778 (TMP-778) is a potent, selective RORγt inhibitor with IC50 of 7 nM in FRET assays and 63 nM in IL-17 promoter assays, with no inverse agonist activity. |
| PC-60453 |
GNE-3500
RORγ inhibitor
|
GNE-3500 (GNE3500) is a potent, selective, and orally bioavailable RORγ inhibitor with IC50 of 47 nM in IL-17 promoter assays. |
| PC-60452 |
VTP-43742
RORγt inhibitor
|
VTP-43742 (Vimirogant, VTP43742) is a highly potent, selective, oral RORγt inverse agonist with Ki/IC50 of 3.5/17 nM respectively. |
| PC-21716 |
W6134
RORγ inhibitor
|
W6134 (RORγ covalent inhibitor 29) is a first-in-class, potent and selective RORγ covalent inhibitor with IC50 of 0.21 uM, targets the Cys320 of RORγ. |
