| Cat. No. |
Product Name |
Information |
| PC-21695 |
ODH-08
RORα agonist
|
ODH-08 is a novel specific small molecule ligand and agonist of RORα with KD value of 8.4 um, shows potent antifibrotic effect. |
| PC-20043 |
JTE-151
RORγt antagonist
|
JTE-151 (JTE151) is a potent selective RORγ antagonist with EC50 of 14 nM, acts by suppressing overactive immune response through inhibition of RORγ related to the activation of Th17 cells. |
| PC-20041 |
BI 730357
RORγt antagonist
|
BI 730357 (Bevurogant, BI-730357) is a potent selective RORγ antagonist with IC50 of 150 nM in reporter gene assays (RGA), inhibits the secretion of IL-17A of PBMCs with IC50 of 24 nM. |
| PC-49473 |
RORγt agonist 8-074
RORγt agonist
|
RORγt agonist 8-074 is a potent, selective RORγt agonist with Kd of 497 nM, shows potent RORγt agonist activity in the Gal4 reporter gene assay with EC50 of 118.7 nM, and EC50 of 19.95 nM in FRET assays. |
| PC-38351 |
BMS-986313
RORγt inhibitor
|
BMS-986313 is a potent, selective, orally active RORγt inverse agonist with EC50 of 3.6 nM in GAL-4 reporter assay in Jurkat cell line, and 50 nM in IL-17 human whole blood assay. |
| PC-38350 |
BMS-986251
RORγt inhibitor
|
BMS-986251 is a potent, selective, orally active RORγt inverse agonist with EC50 of 12 nM in GAL-4 reporter assay in Jurkat cell line, and 24 nM in IL-17 human whole blood assay. |
| PC-73441 |
Retezorogant
RORγ antagonist
|
Retezorogant is a potent, selective retinoid-related orphan receptor gamma (RORγ) antagonist. |
| PC-72400 |
JNJ-61803534
RORγt inverse agonist
|
JNJ-61803534 (JNJ 61803534) is a novel, selective and potent RORγt inverse agonist, inhibits RORγt-driven transcription with IC50 of 9.6 nM in 1-hybrid reporter assays. |
| PC-35886 |
RORC2 inverse agonist 66
|
RORC2 inverse agonist 66 is a potent, selective, and orally bioavailable RORC2 inverse agonist, significantly inhibits the IL-17 production in murine Th17 cells with 92% maximum inhibition (IC50=32 nM). |
| PC-35570 |
RORγt inverse agonist 32
|
RORγt inverse agonist 32 is a potent, orally bioavailable inverse agonist of RORγt with IC50 of 9 nM in SPA binding assays. |
| PC-35085 |
SR1555 hydrochloride
|
SR1555 is a selective RORγ inverse agonist (IC50=1.5 uM) that suppresses T(H)17 cells and stimulates T regulatory cells. |
| PC-60488 |
RORγt-IN-9a
|
A potent, selective, CNS penetrant, orally bioavailable RORγt with pIC50 of 8.3 in FRET assays. |
