| Cat. No. |
Product Name |
Information |
| PC-45419 |
PRE-084 hydrochloride
Sigma 1 receptor agonist
|
PRE-084 is a highly potent, selective sigma-1 receptor agonist with Ki of 2.2 nM, IC50 of 44 nM. |
| PC-42070 |
4-IBP
Sigma receptor agonist
|
4-IBP is a highly potent sigma receptor agonist with Ki of 1.7 nM and 25.2 nM for σ1 and σ2, respectively. |
| PC-21111 |
AZ-66
Sigma receptor antagonist
|
AZ-66 is a highly potent S1R/S2R antagonist with Ki of 0.31/1.76 nM, respectively. |
| PC-21110 |
CM-304
σ2R antagonist
|
CM-304 is a potent, selective sigma-1 receptor (S1R) antagonist with Ki of 3.41 nM, 100-fold selective over S2R. |
| PC-21109 |
CM-398
σ2R ligand
|
CM-398 (CM398) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 0.43 nM, >1000-fold selective over σ1R, produces antinociception and anti-allodynia effects. |
| PC-21108 |
CT-1812
σ2R ligand
|
CT-1812 (CT1812) is a potent, orally active dual σ1R and σ2R ligand with Ki of 63 and 8.5 nM respectively, IC50 of 0.31 uM in neuronal trafficking assays. |
| PC-21107 |
WLB-89462
σ2R ligand
|
WLB-89462 (WLB89462) is a potent, highly selective sigma-2 receptor (σ2R) ligand with Ki of 13 nM, >100-fold selective over σ1R (Ki=1777 nM). |
| PC-21055 |
RC-752
Sigma 1 inhibitor
|
RC-752 is a potent, seletive sigma-1 receptor (S1R) antagonist with Ki of 6.2 nM, 50-fold selective over S2R, shows antinociceptive activity. |
| PC-20968 |
GM310
Sigma-1 agonist
|
GM310 is a small molecule inhibitor of glycolysis, proteotoxicity, inflammation, and impairments in animal models of Alzheime's, Huntington's, and stroke by activation of the Sigma-1 receptor. |
| PC-20740 |
DKR-1677
σ2R/TMEM97 modulator
|
DKR-1677 (DKR1677) is a potent, selective σ2R/TMEM97 modulator with Ki value of 5.1 nM, 45-fold selectivity over σ1R (Ki=230 nM). |
| PC-20739 |
FEM-1689
σ2R/TMEM97 ligand
|
FEM-1689 (FEM1689) is a potent, selective σ2R/TMEM97 binding ligand with Ki value of 11 nM. |
| PC-49695 |
JR1-157
σ2R ligand
|
JR1-157 is a potent selective sigma 2 receptor (σ2R) ligand with Ki value of 47 nM, >10-fold selectivity over σ1R. |
