| Cat. No. |
Product Name |
Information |
| PC-73259 |
IS811
CCR3 antagonist
|
IS811 is a potent, selective CCR3 antagonist with IC50 of 2.0 nM, potently inhibits chemotaxis with EC50 of 19 nM. |
| PC-73250 |
CCR7 inhibitor Cmp1205
CCR7 inhibitor
|
CCR7 inhibitor Cmp1205 is an allosteric ligand and antagonist for human CC chemokine receptor 7 (CCR7) with Kd of 3 nM, suppresses arrestin binding in response to activation by CCL19 with IC50 of 7.3 uM. |
| PC-73249 |
Vercirnon
CCR9 inhibitor
|
Vercirnon (GSK1605786A, CCX282-B) is a potent, selective, orally bioavailable antagonist of CCR9, inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 of 5.4 and 3.4 nM, respectively. |
| PC-73031 |
CCR4-351
CCR4 antagonist
|
CCR4-IN-38 (CCR4-351) is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 50 nM (Chemotaxis inhibition). |
| PC-73030 |
CCR4-IN-31
CCR4 antagonist
|
CCR4-IN-31 is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 40 nM (Ca2+ flux). |
| PC-72905 |
EMU-116
CXCR4 antagonist
|
EMU-116 (EMU-000116) is a potent, selective CXCR4 antagonist with IC50 29.6 nM in Ca2+ flux assay. |
| PC-72896 |
CCR2 inhibitor SD-24
CCR2 inhibitor
|
CCR2 inhibitor SD-24 is a potent selective CCR2 antagonist with pKi of 8.5. |
| PC-72895 |
CCR2 Covalent-IN-14
CCR2 inhibitor
|
CCR2 covalent-IN-14 is a covalent, negative allosteric modulator (NAM) of CCR2, binds to intracellularly pocket of CCR2 with Ki of 4 nM. |
| PC-72668 |
BMS-813160
CCR2/5 inhibitor
|
BMS-813160 (BMS 813160) a potent and selective CCR2/5 dual antagonist with binding IC50 of 6.2/3.6 nM, respectively. |
| PC-72636 |
CXCR7 modulator 18
CXCR7 modulator
|
CXCR7 modulator 18 is a novel potent, selective CXCR7 modulator with Ki of 13 nM, β-arrestin EC50 of 11 nM. |
| PC-72635 |
CXCR7 modulator 20
CXCR7 modulator
|
CXCR7 modulator 20 is a small molecule modulator of the atypical chemokine receptor CXCR7 with Ki of 52 nM. |
| PC-72634 |
ACT-1004-1239
CXCR7 antagonist
|
ACT-1004-1239 is a potent, selective, orally available CXCR7 antagonist with IC50 of 3.2 nM (hCXCR7). |
