| Cat. No. |
Product Name |
Information |
| PC-45482 |
RS102895 hydrochloride
CCR2 antagonist
|
RS102895 hydrochloride is a potent and specific CCR2 antagonist with binding IC50 of 360 nM. |
| PC-45824 |
AMD-070 hydrochloride
CXCR4 antagonist
|
AMD-070 (Mavorixafor) hydrochloride is a potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay. |
| PC-45823 |
AMD-070
CXCR4 antagonist
|
Mavorixafor (AMD-070, AMD-11070) is a potent and selective antagonist of CXCR4 with IC50 of 13 nM in a CXCR4 125I-SDF inhibition binding assay. |
| PC-42391 |
IT1t dihydrochloride
CXCR4 inhibitor
|
IT1t (Isothiourea 1t) dihydrochloride is a highly potent, selective, orally bioavailable CXCR4 inhibitor with binding IC50 of 8 nM for hCXCR4, IC50 of 1.1 nM in Ca2+-mobilization assays. |
| PC-42390 |
IT1t
CXCR4 inhibitor
|
A highly potent, selective, orally bioavailable CXCR4 inhibitor with binding IC50 of 8 nM for hCXCR4, IC50 of 1.1 nM in Ca2+-mobilization assays. |
| PC-21897 |
Maraviroc
CCR5 antagonist
|
Maraviroc (UK-427857) is a potent, selective and orally bioavailable CCR5 inhibitor with IC50 of 3.3 nM, 7.2 nM and 5.2 nM for MIP-1α, MIP-1β and RANTES binding to cell membrane preparations of CCR5-expressing HEK-293, shows broad-spectrum activity against HIV-1. |
| PC-21816 |
VUF11222
CXCR3 agonist
|
VUF11222 is a potent, selective and nonpeptidomimetic CXCR3 agonist with binding pKi of 7.2, and pEC50 of 6.1 in [35S]GTPγS functional assays. |
| PC-21815 |
PS372424 hydrochloride
CXCR3 agonist
|
PS372424 hydrochloride is a potent, selective peptidomimetic agonist of human CXC chemokine receptor 3 (CXCR3) with EC50 of 1.1 uM in calcium flux assays, binding affinity of 42 nM. |
| PC-21814 |
PS372424
CXCR3 agonist
|
PS372424 is a potent, selective peptidomimetic agonist of human CXC chemokine receptor 3 (CXCR3) with EC50 of 1.1 uM in calcium flux assays, binding affinity of 42 nM. |
| PC-21785 |
VUF15485
ACKR3 agonist
|
VUF15485 is a small-molecule agonist of the atypical chemokine receptor ACKR3 with binding pIC50 of 8.3, and pEC50 of 7.6 in BRET-based β-arrestin2 recruitment assay. |
| PC-21470 |
alpha-NETA
CMKLR1 inhibitor
|
alpha-NETA (α-NETA) is a small molecule antagonist of chemerin receptor chemokine-like receptor 1 (CMKLR1), inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 with IC50 of 4.9 uM. |
| PC-21292 |
GPC-100 hydrobromide
CXCR4 antagonist
|
GPC-100 (TG-0054, Burixafor) is a novel small molecule antagonist of CXCR4, shows competitive inhibition of CXCL12 binding to CXCR4 with Ki of 1.6 nM. |
