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Cat. No. Product Name Information
PC-61984

K-777

CCR4 antagonist

K-777 is a potent and selective CCR4 antagonist that inhibits both CCL17 binding and CCL17-induced chemotaxis in Hut78 cells with IC50 of 57 and 8.9 nM respectively.
PC-61981

FLX-475

CCR4 antagonist

FLX-475 (Tivumecirnon) is a novel potent, selective CCR4 antagonist, blocks the migration of regulatory T cells (Treg) specifically into tumors.
PC-61979

ML 604086

ML 604086 (ML604086) is a potent, selective CCR8 inhibitor that inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations with IC50 of 1.3 uM and 1.0 uM respectively in cellular assays.
PC-61969

BMS-741672

CCR2 antagonist

BMS-741672 is a potent, selective CCR2 antagonist for the treatment of neuropathic pain..
PC-61968

Aplaviroc

CCR5 antagonist

Aplaviroc (GSK-873140, GW 873140, AK-602, ONO-4128) is a potent, noncompetitive, allosteric antagonist of the CCR5 receptor with pKb of 8.6.
PC-61967

CP-481715

CCR1 inhibitor

CP-481715 is a potent and selective CCR1 antagonist with Ki of 9.2 nM and IC50 of 74 nM, lacks intrinsic agonist activity.
PC-61966

MLN 3897

CCR1 inhibitor

MLN 3897 is a potent, specific and orally active antagonist of CCR1 with IC50 of 0.8 nM in competition binding assays, 500-fold selectivity over CCR5.
PC-61965

FC131

CXCR4 antagonist

FC131 (cyclo(-D-Tyr-Arg-Arg-Nal-Gly-)) is a selective, cyclopentapeptide CXCR4 antagonist with IC50 of 126 nM, exhibits anti-HIV activity in assays using NL4-3 and IIIB strains with EC50 of 21 nM..
PC-61964

CMPD167

CCR5 antagonist

CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM)..
PC-61688

AZD 1678

CCR4 antagonist

AZD 1678 is a potent, selective orally bioavailable CCR4 receptor antagonist with pIC50 of 8.6 for hCCR4, pIC50 of 9.0 for rCCR4.
PC-61687

AZD 2098

AZD2098 (AZD-2098) is a potent, selective, orally bioavailable CCR4 receptor antagonist with pIC50 of 7.8 for hCCR4, pIC50 of 8.0 for rCCR4.
PC-61582

PF-232798

CCR5 antagonist

PF-232798 (PF-00232798) is a potent CCR5 antagonist with IC50 of <0.1 nM in gp160 fusion assay, exhibits potent broad-spectrum anti-HIV-1 activity.

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