| Cat. No. |
Product Name |
Information |
| PC-26593 |
Huib32
USP32 inhibitor
|
Huib32 is a potent, selective small-molecule inhibitor of USP32 with IC50 of 21.2 nM, high selectivity over other closely related deubiquitinating enzymes (DUBs). |
| PC-25948 |
WW-104
USP10 inhibitor
|
WW-104 is a specific small molecule USP10 inhibitor with IC50 of 16.75 uM and strong binding affinity with SPR Kd of 237 nM, shows no detectable inhibitory activity against USP7. |
| PC-25852 |
BB07CA902
mUSP18 inhibitor
|
BB07CA902 is a potent, specific, covalent inhibitor of interferon-stimulated gene 15 (ISG15) protease murine USP18 (mUSP18) with IC50 of 35 nM, effectively increases ISGylation levels in cells by inhibiting mUSP18 activity. |
| PC-25570 |
OAT-4828
USP7 inhibitor
|
OAT-4828 is a potent, and selective USP7 inhibitor with IC50 of 22 nM in enzymatic assay and 33 nM in reporter assay (Ub-CHOP reporter system). |
| PC-25548 |
WCY-8-67
USP5 inhibitor
|
WCY-8-67 is a potent, selective inhibitor of deubiquitinating enzyme (DUB) USP5 with IC50 of 0.33 uM and SPR Kd of 5.73 uM, inhibits the growth of t(8;21) AML cells. |
| PC-25366 |
CAS-010
USP28 inhibitor
|
CAS-010 (CAS-13312-010) is a potent, selective and ubiquitin-competitive inhibitor of USP28 with IC50 of 4.2 nM in UbRho assays, disrupts the 53BP1-USP28 interaction and reduces p53 target gene transactivation. |
| PC-25113 |
USP14 inhibitor AKOS
USP14 inhibitor
|
USP14 inhibitor AKOS (AKOSB018304) is a specific and covalent USP14 inhibitor with IC50 of 0.98 uM for USP14 deubiquitinase activity, also is a small molecule chikungunya virus (CHIKV) inhibitor. |
| PC-24867 |
Mitoxantrone
USP11 inhibitor
|
Mitoxantrone is a specific small molecule inhibitor of USP11 with IC50 of 3.15 uM, impacts PDA cell survival with an IC50<10 nM, also is a potent topoisomerase II inhibitor and inhibits protein kinase C (PKC) activity with IC50 of 8.5 uM. |
| PC-24036 |
TNG348
USP1 inhibitor
|
TNG348 is a potent, a selective, allosteric and reversible USP1 inhibitor with IC50 of 98.6 nM in AlphaLISA-based measurement of ub-PCNA induction in MDA-MB-436 cells. |
| PC-23736 |
USP30-I-1
USP30 inhibitor
|
USP30-I-1 (USP30-IN-1) is a potent, selective and covalent inhibitor of mitochondrial deubiquitinating (DUB) enzyme USP30 with IC50 of 94 nM, shows no significant activity against other 40 endogenous DUBs. |
| PC-23143 |
IsoLiPro
USP11 inhibitor
|
IsoLiPro is a novel small molecule USP11 inhibitor, reduces the USP11 protein level and suppressesthe USP11-mediated substrate deubiquitination. |
| PC-22877 |
YCH3124
USP7 inhibitor
|
YCH3124 is a potent, selective USP7 inhibitor with IC50 of 41.9 nM and Kd of 156 nM, exhibits minimal inhibition against other USPs, including USP1, USP4, USP8, USP9X, USP15, and USP25. |
