| Cat. No. |
Product Name |
Information |
| PC-38348 |
LS‐106
EGFR mutant inhibitor
|
LS-106 is a novel, fourth‐generation EGFR inhibitor against C797S mutation, targeting both EGFR19del/T790M/C797S and EGFRL858/T790M/C797S with selectivity over EGFRwt. |
| PC-38343 |
Rezivertinib
EGFR inhibitor
|
Rezivertinib (BPI-7711) is a novel third-generation EGFR tyrosine kinase inhibitor selective for EGFR-sensitizing and T790M mutations, shows potential against T790M-mediated drug resistance. |
| PC-38342 |
Almonertinib
EGFR inhibitor
|
Aumolertinib (HS-10296) is a novel, third-generation EGFR tyrosine kinase inhibitor (EGFR TKI) that targets both EGFR-sensitizing and T790M resistance mutations with IC50 of 0.37 nM (T790M), 0.21 nM (del19/T790M), 0.29 nM(L858R/T790M), and 3.39 nM (EGFR WT). |
| PC-38341 |
Befotertinib
EGFR inhibitor
|
Befotertinib (D-0316) is an orally active, third-generation EGFR tyrosine kinase inhibitor that is selective for both EGFR-TKI sensitizing and T790M resistance mutations in NSCLC. |
| PC-73295 |
DDC-03-024-01
EGFR mutant inhibitor
|
DDC-03-024-01 is a potent, mutant-selective allosteric inhibitor of EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) mutants with IC50 of 10 nM. |
| PC-73154 |
Mobocertinib succinate
EGFR mutant inhibitor
|
Mobocertinib succinate (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM. |
| PC-73153 |
Mobocertinib
EGFR mutant inhibitor
|
Mobocertinib (TAK-788) is a potent, mutant-selective, irreversible inhibitor of EGFR ex20ins mutations with IC50 of 2.7 to 22.5 nM. |
| PC-73140 |
BDTX-189
EGFR mutant inhibitor
|
BDTX-189 (Tuxobertinib) is a potent, selective, irreversible inhibitor of allosteric EGFR and HER2 mutant variants. |
| PC-72416 |
EMI1
COPB2 binder
|
EMI1 (EGFR MaMTH Inhibitor 1, ChemBridge 5213777) is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S activating mutant inhibitor, inhibits viability of PC9 EGFR ex19del/T790M/C797S with EC50 of 115 nM, potently reducing the interaction of EGFR triple mutant with Shc1 in MaMTH-DS assays. |
| PC-72058 |
AL906
EGFR inhibitor
|
AL906 (AL 906) is a novel potent, selective EGFR inhibitor with IC50 of 12 nM (EGFR phosphorylation). |
| PC-38118 |
NSC81111
|
NSC81111 is a highly potent EGFR-TK inhibitor with IC50 of 0.15 nM. |
| PC-35996 |
NS-062
|
NS-062 (NS062) is a novel, specific targeted covalent inhibitor that shows high reactivity toward Cys797 of EGFR. |
