| Cat. No. |
Product Name |
Information |
| PC-45681 |
Anlotinib
|
Anlotinib (AL-3818) is a novel multi-target tyrosine kinase that primarily inhibit VEGFR2/3, FGFR1-4, PDGFR α/β, c-Kit, and Ret. |
| PC-42500 |
Afatinib dimaleate
EGFR inhibitor
|
Afatinib (BIBW 2992) dimaleate is an irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively. |
| PC-42499 |
Afatinib
EGFR inhibitor
|
Afatinib (BIBW 2992) is an irreversible, dual EGFR/HER2 inhibitor with IC50 of 0.5/0.4/10/14 nM for wt EGFR/EGFR L858R/EGFR L858R+T790M/HER2 respectively. |
| PC-44668 |
Poziotinib
pan-HER inhibitor
|
Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4. |
| PC-44706 |
AZD-9291
mutant EGFR inhibitor
|
Osimertinib (AZD-9291) is a potent, selective, third-generation irreversible inhibitor of mutant EGFR with IC50s of 1/12/5 nM for L858R-T790M/L858R/L861Q respectively. |
| PC-45812 |
Pelitinib
EGFR inhibitor
|
Pelitinib (EKB-569, WAY-EKB 569) is a potent, selective, orally active, irreversible inhibitor of EGFR with IC50 of 80 nM. |
| PC-45891 |
Gefitinib
EGFR inhibitor
|
Gefitinib (ZD-1839) is a potent, selective, orally active EGFR inhibitor with IC50 of 23 nM. |
| PC-42486 |
BMS-599626
|
BMS-599626 (AC480) is a potent, selective inhibitor of EGFR and HER2 with IC50 of 20 nM and 30 nM. |
| PC-42158 |
AEE-788
EGFR inhibitor
|
AEE-788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively. |
| PC-42640 |
Varlitinib
|
Varlitinib (ARRY-334543) is a potent, orally active, ATP-competitive, selective, reversible inhibitor of ErbB1 and ErbB2. |
| PC-45549 |
AZD3759
EGFR inhibitor
|
AZD3759 is a potent, orally active, BBB-penetrating EGFR inhibitor (IC50=7.2 nM, L858R pEGFR). |
| PC-42087 |
EAI-045
EGFR inhibitor
|
EAI-045 (EAI045) is a potent, mutant-selective allosteric EGFR inhibitor with IC50 of 3 nM for double mutant L858R/T790M in biochemical assays at 1 mM ATP. |
