| Cat. No. |
Product Name |
Information |
| PC-21212 |
MTX-241F
EGFR inhibitor
|
MTX-241F (MTX241F) is a potent, highly selective and brain-penetrant inhibitor of EGFR, PI3K and DNA-PK with IC50 of 3 nM, 87 nM (PI3Kα) and 5.5 nM, respectively. |
| PC-20905 |
SDT-011
EGFR-mAb inhibitor
|
SDT-011 (SDT011) is a small molecule that effectively blocks the binding of anti-EGFR monoclonal antibodies to EGFR, blocks cetuximab-EGFR binding by 62% at 10 uM, binds to EGFR with Kd of 1.7 nM in MST assays. |
| PC-20818 |
HNPMI
EGFR inhibitor
|
HNPMI is a small molecule inhibitor of epidermal growth factor receptor (EGFR) with the anticancer potential against various cancers. |
| PC-20781 |
Mubritinib
HER2 inhibitor
|
Mubritinib (TAK-165) is a potent inhibitor of human epidermal growth factor receptor 2 (HER2, ERBB2) tyrosine kinase with IC50 of 6 nM, also is a potent Complex I inhibitor with IC50 of 51 nM. |
| PC-20174 |
ER121
mutant EGFR inhibitor
|
ER121 (ER-121) is a potent, dual kinase inhibitor targeting both mutant EGFR and activated erbB2 with IC50 of 0.08/0.15 nM (EGFR C797S/EGFR WT, ATP=10 uM). |
| PC-20044 |
Mifanertinib
EGFR inhibitor
|
Mifanertinib is a potent selective EGFR and HER2 kinase inhibitor with potential for for treatment of cancer. |
| PC-49519 |
HCD3514
EGFR C797S inhibitor
|
HCD3514 is a novel potent, selective, fourth-generation EGFR inhibitor targeting C797S triple mutation, strongly inhibits EGFRL858R/T790M/C797S and EGFR19del/T790M/C797S mutations with IC50 of 1.0 and 2.0 nM, respectively. |
| PC-49395 |
TAS2940
pan-ERBB inhibitor
|
TAS2940 (TAS-2940) is a potent, selective, orally active, irreversible and brain-penetrable pan-ERBB inhibitor. |
| PC-38733 |
HKI-357
EGFR inhibitor
|
HKI-357 is a potent, irreversible inhibitor of ErbB2 (HER2) and EGFR with IC50 values of 33 and 34 nM respectively. |
| PC-38641 |
LDC0496
EGFR inhibitor
|
LDC0496 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome. |
| PC-38640 |
LDC8201
EGFR inhibitor
|
LDC8201 is a potent, covalent, wild type-sparing inhibitor of EGFR exon20 insertion mutations, exhibits intense inhibitory potency toward EGFR and Her2 exon20 insertion mutations as well as selectivity over wild type EGFR and within the kinome. |
| PC-38536 |
TX1-85-1
Her3 (ErbB3) inhibitor
|
TX1-85-1 is a potent, selective, irreversible and covalent inhibitor of pseudokinase Her3 (ErbB3) with IC50 of 23 nM in FRET-based binding assay. |
