| Cat. No. |
Product Name |
Information |
| PC-73366 |
JBJ-09-063
EGFR mutant inhibitor
|
JBJ-09-063 is a potent, mutant-selective allosteric EGFR inhibitor against EGFR L858R, T790M and C797S mutations, with IC50 of <0.1 nM for recombinant EGFR L858R/T790M kinase domain. |
| PC-73104 |
BI-4020
EGFR mutant inhibitor
|
BI-4020 (BI 4020) is a potent, next generation, wt-sparing inhibitor of EGFR mutant T790M and/or C797S, and EGFRdel19 T790M C797S (0.2 nM). |
| PC-73088 |
DBPR112
EGFR mutant inhibitor
|
DBPR112 (DBPR 112) is a highly potent, selective inhibitor of EGFR mutant L858R/T790M (IC50=48 nM) and exon 20 insertion mutations. |
| PC-72985 |
(Rac)-JBJ-04-125-02
EGFR T790M/L858R inhibitor
|
(Rac)-JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM. |
| PC-72984 |
JBJ-04-125-02
EGFR T790M/L858R inhibitor
|
JBJ-04-125-02 is a potent, mutant-selective, allosteric inhibitor of EGFR T790M/L858R with IC50 of 0.26 nM. |
| PC-72903 |
BLU-945
mutant EGFR inhibitor
|
BLU-945 (ZL-2313, BLU945, BLU 945) is a potent, mutant-selective inhibitor of EGFR T790M/C797S and EGFR+/T790M mutations (IC50<1 nM). |
| PC-72415 |
EMI66
COPB2 binder
|
EMI66 (EMI-66) is a small molecule that attenuates RTK expression and signalling and alters the electrophoretic mobility of Coatomer Protein Complex Beta 2 (COPB2, binding Kd=1.51 uM) in lung cancer cells. |
| PC-72379 |
AC3573
HER3 inhibitor
|
AC3573 (AC-3573) is a potent, specific small molecule inhibitor of HER3 with IC50 of 4 uM. |
| PC-72266 |
SPH5030
HER2 mutant inhibitor
|
SPH5030 is a selective, potent, and irreversible HER2 mutants inhibitor with IC50 of <1 nM against HER2 D769H, D769Y, V777L and R896C mutants. |
| PC-38187 |
JCN037
EGFR inhibitor
|
JCN037 (JCN 037, JGK037) is novel potent, brain-penetrant, noncovalent EGFR TKI with IC50 of 2.49 nM. |
| PC-38170 |
CH7233163
mutant EGFR inhibitor
|
CH7233163 is a novel potent, selective mutant EGFR-Del19/T790M/C797S inhibitor with IC50 of 0.28 nM in biochemical assays. |
| PC-38101 |
Sunvozertinib
EGFR inhibitor
|
DZD9008 (Sunvozertinib) is an oral, potent, irreversible, wild type-selective EGFR inhibitor against EGFR or HER2 Exon20ins and other mutations (IC50=0.4-2.1 nM). |
