| Cat. No. |
Product Name |
Information |
| PC-21234 |
XL888
HSP90 inhibitor
|
XL888 is a potent small molecule inhibitor of HSP90 with IC50 of 24 nM, inhibits cell proliferation of multiple cancer cell types. |
| PC-20807 |
HLQ2H
Msi3 inhibitor
|
HLQ2H (Msi3 inhibitor 2H) is a first-in-class, specific inhibitor of fungal Hsp110 molecular chaperone Msi3, inhibits the holdase activity of Msi3 (IC50=5.02 uM) as well as the growth and viability of C. albicans. |
| PC-49868 |
Debio 0932
HSP90 inhibitor
|
Debio 0932 (CUDC-305, RGRN-305) is a highly potent, oral and BBB-penetrant HSP90 inhibitor, shows high affinity for HSP90alpha/beta and HSP90 complex derived from cancer cells with IC50 of 100 nM and 48.8 nM, respectively. |
| PC-49317 |
PLTFBH
DNAJA1 inhibitor
|
PLTFBH is a cell-active small molecule inhibitor of DNAJA1, binds to and reduces protein levels of DNAJA1 and several other HSP40/J-domain proteins (JDPs), specifically reduces conformational mutp53 levels similar to PLIHZ. |
| PC-38632 |
SL-145
HSP90 inhibitor
|
SL-145 is a novel C-terminal HSP90 inhibitor, induces apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling. |
| PC-73319 |
CCT361814
HSF1 inhibitor
|
CCT361814 (NXP800) is a potent, selective and orally bioavailable inhibitor of HSF1 pathway with IC50 of 94 nM (SK-OV-3, HSP72 cell-based ELISA). |
| PC-73133 |
Apoptozole
HSP70 inhibitor
|
Apoptozole is a inhibits the ATPase activity of HSP70 and Hsc70 by binding to ATPase domain, induces an array of apoptotic phenotypes in cancer cells. |
| PC-73076 |
DDO-5936
Hsp90-Cdc37 inhibitor
|
DDO-5936 (DDO5936) is a cell-active, specidic small-molecule inhibitor of Hsp90-Cdc37 protein-protein interaction (PPI) without ATPase inhibition, binds to Hsp 90 with Kd of 3.86 uM. |
| PC-73010 |
Foldamer 33
HSP110 inhibitor
|
Foldamer 33 is a small molecule HSP110 inhibitor, directly binds to the nucleotide-binding domain (NBD) of HSP110, blocks HSP110 chaperone function and colorectal cancer growth. |
| PC-72711 |
PU-HZ151
HSP90 inhibitor
|
PU-HZ151 (Icapamespib, PU HZ151) is a specific CNS-directed epichaperome probe, with selectivity for epichaperomes over the individual chaperome membersm, inhibits HSP90 with EC50 of 5 nM in the FP assays. |
| PC-72710 |
PU-H71
Hsp90 inhibitor
|
PU-H71 (Zelavespib, NSC 750424) is a potent and selective inhibitor of Hsp90 (Heat shock protein 90) with IC50 of 51 nM in MDA-MB-468 cells. |
| PC-72704 |
AIMP2-DX2 inhibitor 1
AIMP2-DX2 inhibitor
|
AIMP2-DX2 inhibitor 1 (Compound 1) is a specific chemical probe that can inhibit the tumor-promoting interaction between AIMP2-DX2 and HSP70 (IC50=2.9 uM). |
