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Cat. No. Product Name Information
PC-63538

T1551

PRMT5 inhibitor

T1551 is a novel, potent and specific PRMT5 inhibitor with IC50 of 34.1 uM, exhibits anti-proliferation on A549 cell with IC50 of 11.2 uM.
PC-63461

LLY-283

LLY-283 (LLY283) is a potent, selective inhibitor of arginine methyltransferase 5 (PRMT5) with IC50 of 22 nM.
PC-63250

BAY-6035

BAY-6035 is a potent, peptide-competitive inhibitor of histone methyltransferase SMYD3, inhibits in vitro methylation of MEKK2 peptide with IC50 of 88 nM, >100-fold selectivity over other HMTases.
PC-43301

EPZ020411 hydrochloride

PRMT6 inhibitor

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).
PC-43300

EPZ020411

PRMT6 inhibitor

EPZ020411 is a potent, selective PRMT6 inhibitor with IC50 of 10 nM, displays 10-fold and 20-fold selectivity over PRMT1/8, and >100-fold over other histone methyltransferases (PRMT3/4/5/7).
PC-43259

GSK503

EZH2 inhibitor

GSK503 is a potent, specific EZH2 methyltransferase inhibitor that inhibits the methyltransferase activity of WT and mutant EZH2 with similar potency (Ki app=3-27 nM).
PC-43165

EPZ015666

PRMT5 inhibitor

EPZ015666 (GSK3235025) is a potent, selective, orally available inhibitor of PRMT5 with Ki/IC50 of 5/22 nM, displays broad selectivity against a panel of other histone methyltransferases.
PC-63229

PJ-68

PRMT5 inhibitor

PJ-68 is a potent, selective inhibitor of arginine methyltransferase PRMT5 with IC50 of 517 nM, shows no inhibitory activity against type I PRMT family members ( (PRMT1, 3, 4, 6, and 8).
PC-43110

A-366

G9a/GLP inhibitor

A-366 is a potent, highly selective inhibitor of histone methyltransferase G9a/GLP with IC50 of 3/38 nM, >1,000-fold selectivity for G9a over 21 other methyltransferases.
PC-42984

UNC0379 trifluoroacetate

SETD8 inhibitor

UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.
PC-42983

UNC0379

SETD8 inhibitor

UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 with IC50 of 7.3 uM.
PC-63136

MS012

G9a-like protein inhibitor

MS012 is a potent and selective inhibitor of G9a-Like Protein (GLP) lysine methyltransferase with IC50 of 7 nM, shows >30-fold selectivity for GLP over G9a and other methyltransferases..

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