| Cat. No. |
Product Name |
Information |
| PC-21038 |
KTX-1001
NSD2 inhibitor
|
Gintemetostat (KTX-1001) is a potent, selective histone methyltransferase NSD2 (WHSC1, MMSET) inhibitor targeting the catalytic SET domain. |
| PC-21012 |
EML734
PRMT7/9 inhibitor
|
EML734 is a selective small molecule inhibitor of protein arginine methyltransferase isoforms, PRMT7 and PRMT9 with IC50 of 0.32 and 0.89 uM, respectively. |
| PC-20832 |
SETDB1 activator (R,R)-59
SETDB1 activator
|
(R,R)-59 is a small-molecule ligand activator for methyltransferase SETDB1 Triple Tudor Domain (3TD reader domain) with binding IC50 of 1.2 uM in TR-FRET assays, specifically promotes in vitro SETDB1-mediated methylation of lysine 64 of protein kinase Akt1. |
| PC-20645 |
HKMTI-1-005
G9a/GLP/EZH2 inhibitor
|
HKMTI-1-005 is a potent, substrate-competitive dual inhibitor of EZH2 and the closely related G9a/GLP H3K9 methyltransferases with IC50 of 0.1 uM (EHMT2). |
| PC-20553 |
Igf2bp1 inhibitor 7773
Igf2bp1 inhibitor
|
Igf2bp1 inhibitor 7773 is a specific small molecule inhibitor of Igf2bp1, binds to RNA binding domains of Igf2bp1, inhibits Igf2bp1 binding of Kras 6 RNA with IC50 of 30 uM. |
| PC-20135 |
UZH1a
METTL3 inhibitor
|
UZH1a is a potent, selective and cell‐permeable inhibitor of METTL3 with IC50 of 0.28 uM, 100-fold more potent than enantiomer UZH1b. |
| PC-20124 |
DC-PRC2in-01
EZH2-EED inhibitor
|
DC-PRC2in-01 is a small molecule PRC2 inhibitor targeting EZH2-EED interaction with affinity Kd of 4.56 uM, decreases global H3K27me3 levels in cancer cells. |
| PC-20002 |
UNC2327
PRMT3 inhibitor
|
UNC2327 (UNC-2327) is a potent, allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) with IC50 of 230 nM. |
| PC-49859 |
Emilumenib
Menin-MLL1 inhibitor
|
DS-1594a (Emilumenib) is a highly potent Menin-MLL1 inhibitor with IC50 of 1.4 nM in cell-free AlphaLISA assays, displays selective growth inhibition against AML and ALL cells with MLL1-r or NPM1c. |
| PC-49814 |
SMYD3 inhibitor 49
SMYD3 inhibitor
|
SMYD3 inhibitor 49 is a potent and selective SMYD3 inhibitor with IC50 of 6.3 and 44 nM in biochemical and cellular MEKK2me assays, respectively. |
| PC-49813 |
EM127
SMYD3 inhibitor
|
EM127 is a potent, site-specific covalent, second-generation inhibitor of SMYD3 methyltransferase. |
| PC-49729 |
BRD9539
G9a inhibitor
|
BRD9539 is a small molecule inhibitor of histone hethyltransferase of G9a (euchromatin histone methyltransferase 2, EHMT2) with IC50 of 6.3 uM. |
