| Cat. No. |
Product Name |
Information |
| PC-42923 |
MM-102 trifluoroacetate
MLL1/WDR5 inhibitor
|
MM-102 trifluoroacetate is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM. |
| PC-42922 |
MM-102
MLL1/WDR5 inhibitor
|
MM-102 is a high-affinity, small-molecule peptidomimetic inhibitor of MLL1/WDR5 protein-protein interaction with Ki of 2.4 nM. |
| PC-45489 |
PFI-2 hydrochloride
SETD7 inhibitor
|
PFI-2 ((R)-PFI-2) hydrochloride is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively. |
| PC-45488 |
PFI-2
SETD7 inhibitor
|
PFI-2 ((R)-PFI-2) is a first-in-class, potent and selective inhibitor of SETD7 methyltransferase with Ki app/IC50 of 0.33/2 nM, respectively. |
| PC-25966 |
SKLB06489
Type I PRMTs inhibitor
|
SKLB06489 is a potent, selective type I PRMTs inhibitor with IC50 of 64.55, 4.21, and 51.27 nM for PRMT1, PRMT6, and PRMT8 respectively. |
| PC-25914 |
FLAV-27
G9a inhibitor
|
FLAV-27 is a potent, selective, SAM-competitive, brain-penetrant inhibitor of histone methyltransferase G9a with IC50 of 0.6 nM, with excellent selectivity over GLP (3.2% inhibition at 1 uM). |
| PC-25913 |
DCG066
G9a inhibitor
|
DCG066 is a novel small molecule inhibitors of lysine methyltransferase G9a, inhibits G9a methyltransferase activity with IC50 of 6.5 uM. |
| PC-25825 |
I3IN-002
IGF2BP3 inhibitor
|
I3IN-002 is a small molecule inhibitor of RNA-binding protein IGF2BP3, inhibits IGF2BP3-RNA interactions and shows leukemic cell growth-inhibitory activity with IC50 of ~2 µM in wild-type SEM-cells. |
| PC-25711 |
Heterochromatin protein 1 inhibitor (R)-18
HP1 inhibitor
|
Heterochromatin protein 1 inhibitor (R)-18 is a small-molecule inhibitor of heterochromatin protein 1 (HP1), inhibits the HP1/H3K9me3 interaction with IC50 of 18.1 uM. |
| PC-25566 |
BMF-219
Menin inhibitor
|
BMF-219 (Icovamenib) is a potent, selective and covalent irreversible menin inhibitor, inhibits the growth of KRAS-mutated solid tumors with G12C, G12D, and G12V KRAS mutations. |
| PC-25565 |
RK-552
NSD2 inhibitor
|
RK-0080552 (RK-552) is a potent, specific small molecule NSD2 inhibitor with IC50 of 0.11 uM, weakly inhibits G9a (IC50=1.2 uM) and does not inhibit SET7/9. |
| PC-25506 |
LH168
WDR5 inhibitor
|
LH168 is a potent, exquisitely selective WDR5 chemical probe inhibitor with EC50 of 10 nM in cellulo target engagement NanoBRET assays, SPR KD of 1.9 nM. |
