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Cat. No. Product Name Information
PC-21940

UNC1999

EZH2 inhibitor

UNC1999 is a potent, selectice SAM-competitive and orally bioavailable inhibitor of EZH2/EZH1 with IC50 of <10 nM/45 nM, respectively.
PC-21939

GSK126

EZH2 inhibitor

GSK126 (GSK2816126A) is a potent, highly selective, and SAM-competitive inhibitor of EZH2 methyltransferase with IC50 of 9.9 nM.
PC-21938

Tazemetostat

EZH2 inhibitor

Tazemetostat (EPZ-6438) is a potent, selective, SMA-competitive and orally available EZH2 inhibitor with IC50 of 11 and 16 nM in peptide assay and nucleosome assay, respectively.
PC-21930

CPI-360

EZH2 inhibitor

CPI-360 is a potent, selective EZH2 inhibitor with IC50 of 0.5 and 2.5 nM for wild-type EZH2 and Y641N mutant EZH2, respectively.
PC-21857

BI-9321 trihydrochloride

NSD3 inhibitor

BI-9321 (BI 9321) trihydrochloride is a potent, selective and cellular active inhibitor of the NSD3-PWWP1 domain with SPR Kd of 166 nM.
PC-21842

GSK3368715 dihydrochloride

Type 1 PRMT inhibitor

GSK3368715 (EPZ019997, GSK-3368715) dihydrochloride is a potent, reversible and SAM uncompetitive type I PRMT inhibitor with Kiapp of 1.5 to 81 nM for PRMT1, 3, 4, 6, and 8.
PC-21832

WDR5 WBM site inhibitor 7k

WDR5 WBM site inhibitor

WDR5 WBM site inhibitor 7k is a selective small molecule inhibitor of WDR5 WBM binding site with Ki of 107 nM, inhibits lncRNA-WDR5 complex formation.
PC-21619

EPZ004777

DOT1L inhibitor

EPZ004777 is a potent, selective inhibitor of DOT1L with Ki of 0.3 nM and IC50 of 0.4 nM, selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes.
PC-21618

Pinometostat

DOT1L inhibitor

Pinometostat (EPZ-5676) is a potent and selective inhibitor of DOT1L histone methyltransferase activity with Ki of 0.08 nM, 37000-fold selectivity over other methyltransferases.
PC-21606

KMI169

KMT9 inhibitor

KMI169 (KMI-169) is a potent and selective lysine methyltransferase 9 (KMT9) inhibitor with ITC Kd of 25 nM and enzymatic IC50 of 50 nM.
PC-21568

BN104

menin-MLL inhibitor

BN104 (BNM-1192) is a potent, highly selective small molecule menin-MLL inhibitor, BNM-1192 is very potent against leukemia cell lines with MLL-fusion protein and NPM1 mutant (MV-4-11 (AF4 fusion), IC50=3.5 nM).
PC-21491

DP308

53BP1 inhibitor

DP308 is a novel and effective 53BP1 tandem Tudor domain (TTD) inhibitor, disrupts the binding between 53BP1 and H4K20me2 peptide with IC50 of 1.69 uM.

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