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Cat. No. Product Name Information
PC-45726

MI-463

Menin-MLL inhibitor

MI-463 is a highly potent and orally bioavailable small-molecule inhibitor of menin-MLL (IC50=15.3 nM, Kd=9.9 nM).
PC-42673

BIX-01294

G9a inhibitor

BIX-01294 is a specific small molecule G9a histone methyltransferase inhibitor with IC50 of 1.7 uM.
PC-45576

AMI-1

PRMTs inhibitor

AMI-1 (Arginine methyltransferase inhibitor 1) is a specific inhibitor of PRMTs (protein arginine methyltransferases), but not lysine methyltransferases.
PC-45050

BRD-4770

HMTase inhibitor

A SAM mimetic that selectively inhibits a subset of Histone Methyltransferase (HMTs), including G9a, in biochemical assays and in cells.
PC-44291

UNC0638

G9a/GLP inhibitor

UNC0638 (UNC 0638) is a potent, selective, substrate-competitive inhibitor of G9a (EHMT2) and GLP (EHMT1) with IC50 of <15 nM and 19 nM in SAHH-coupled assays, respectively,
PC-45120

OICR-9429

WDR5-MLL inhibitor

OICR-9429 is a potent, selective, small-molecule antagonist of WDR5-MLL interaction that binds to WDR5 with Kd of 93±28 nM.
PC-45608

EPZ-031686

SMYD3 inhibitor

EPZ-031686 (EPZ 031686) is a potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM, Cell IC50= 36 nM).
PC-42405

GSK3326595

PRMT5 inhibitor

Pemrametostat (GSK3326595, EPZ015938) is a potent, selective, reversible and orally active PRMT5 inhibitor with IC50 of 22 nM.
PC-42321

EED226

PRC2 inhibitor

EED226 (EED 226) is a potent, selective, orally bioavailable PRC2 inhibitor that directly binds to the H3K27me3 binding pocket of EED (IC50=22 nM).
PC-45115

EPZ-011989 trifluoroacetate

EZH2 inhibitor

EPZ-011989 trifluoroacetate is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.
PC-45114

EPZ-011989

EZH2 inhibitor

EPZ-011989 (EPZ011989) is a potent, selective, orally bioavailable inhibitor of EZH2 with Ki of < 3 nM.
PC-42097

EPZ-015866

PRMT5 inhibitor

EPZ-015866 (GSK-591, GSK-3203591) is a potent, selective protein methyltransferase 5 (PRMT5) inhibitor with IC50 of 4 nM.

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