| Cat. No. |
Product Name |
Information |
| PC-21093 |
GM6001
MMP inhibitor
|
GM6001 (Ilomastat) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor with IC50 of 1.5/1.1/1.9/0.5 nM for MMP-1/2/3/9, respectively. |
| PC-20539 |
AZD1236
MMP-9/12 inhibitor
|
AZD1236 is a potent, selective MMP-9 and MMP-12 inhibitor with IC50 of 4.5 and 6.1 nM respectively, >10-fold selectivity to MMP-2 and MMP-13 and >350-fold selectivity to other MMPs. |
| PC-20538 |
MMP118
MMP-12 inhibitor
|
MMP118 is a potent, selective and orally bioavailable matrix metalloproteinase-12 (MMP-12) inhibitor with IC50 of 1.0 nM (hMMP-12), 1980- and 154-fold selectivity over MMP-13 and MMP-8 respectively. |
| PC-20536 |
CM-352
MMP-3/MMP-10 inhibitor
|
CM-352 (CM352) is an antihemorrhagic agent that potently inhibit MMP-10 and MMP-3 (IC50 of 12 and 15 nM, respectively), inhibits fibrinolysis in human whole blood functional assays with EC50 of 0.7 nM. |
| PC-20535 |
Trimeric MMP-9 inhibitor 7
MMP-9 inhibitor
|
Trimeric MMP-9 inhibitor 7 is a bivalent carboxylate inhibitor to block the catalytic activity of stable MMP-9 trimers with IC50 of 26 nM. |
| PC-20476 |
JTP-96193
TACE inhibitor
|
JTP-96193 (JTP96193) is a potent, selective TNF-α converting enzyme (TACE/ADAM17) inhibitor with IC50 of 5.4 nM, >1800-fold selectivity against ADAM10. |
| PC-73394 |
GLPG1972
ADAMTS5 inhibitor
|
GLPG1972 (Aldumastat, S201086) is a potent and selective small-molecule inhibitor of ADAMTS5 with IC50 of 19 and <23 nM against human and rat ADAMTS5, respectively. |
| PC-72743 |
ADAM17 inhibitor SN-4
ADAM17 inhibitor
|
ADAM17 inhibitor SN-4 is a novel specific inhibitor of A disintegrin and metalloproteinase 17 (ADAM17), inhibits TNF-α cleavage by SN-4 in cells with IC50 of 3.22 uM. |
| PC-72450 |
RF036
MMP-13 inhibitor
|
RF036 (MMP-13i) is a potent, highly selective MMP-13 inhibitor with IC50 of 2.7 nM, does not inhibit MMP-1, -2, -8, -9, and -14 (IC50 values >5,000 nM). |
| PC-72040 |
PG-116800
MMP inhibitor
|
PG-116800 is a selective, oral matrix metalloproteinase (MMPs) inhibitor with significant antiremodeling effects in animal models of MI and ischemic heart failure. |
| PC-72039 |
Rebimastat
MMP inhibitor
|
Rebimastat (BMS-275291, D2163) is a potent, broad spectrum matrix metalloproteinase (MMPs) inhibitor with potential antineoplastic activity, shows nM potency against MMP-1/2/7/9/14. |
| PC-72036 |
SC-78080
MMP inhibitor
|
SC-78080 (SD-2590) is a potent, selective inhibitor of MMP2/9/13 with IC50 of <0.1/0.18/<0.1 nM, respectively. |
