| Cat. No. |
Product Name |
Information |
| PC-49071 |
VU0364739
PLD2 inhibitor
|
VU0364739 is a potent, selective allosteric inhibitor of phospholipase D2 (PLD2) with cellular IC50 of 20 nM, >75-fold selectivity over PLD1. |
| PC-38749 |
ABD298
ABHD13 inhibitor
|
ABD298 is a potent, selective ABHD13 inhibitor, inhibits HEK293T cells expressing recombinant mouse ABHD13 with IC50 of 0.98 uM. |
| PC-38533 |
ML226
ABHD11 inhibitor
|
ML226 is a potent, selective, covalent inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with IC50 values of 15 and 0.68 nM in vitro and in situ, respectively. |
| PC-38505 |
ML211
LYPLA1/LYPLA2 inhibitor
|
ML211 is a potent, dual LYPLA1/LYPLA2 inhibitor with IC50 of 17/31 nM, respectively, displays no activity against ABHD11 and other 20 serine hydrolases. |
| PC-72955 |
VU0285655-1
PLD2 inhibitor
|
VU0285655-1 (BML280) is a potent, selective inhibitor of PLD2, prevents caspase-3 cleavage and reduction in cell viability induced by high glucose, induces autophagy in colorectal cancer cells. |
| PC-72954 |
VU0359595
PLD1 inhibitor
|
VU0359595 (VU 0359595) is a potent, selective phospholipase D (PLD) inhibitor with cell IC50 of 4 nM. |
| PC-38219 |
LEI-401
NAPE-PLD inhibitor
|
LEI-401 (LEI 401) is a potent, selective, brain active N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) inhibitor with Ki of 2.7 nM. |
| PC-36162 |
AK106-001616
cPLA2 inhibitor
|
AK106-001616 (AK 106-001616) is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) with IC50 of 3.8 nM (human cPLA2 enzyme). |
| PC-35979 |
LEI110
PLA2G16 inhibitor
|
LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6). |
| PC-35798 |
HT105
CD95-PLCγ1 inhibitor
|
HT105 (HT-105) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM. |
| PC-35797 |
DB550
|
DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without
affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM. |
| PC-35796 |
DO264
|
DO264 (DO-264) is a potent, selective, reversible and vivo-active inhibitor of ABHD12 that inhibits ABHD12-dependent lyso-PS lipase activity of membrane lysates from mouse brain with IC50 of 2.8 nM, blocks lyso-PS hydrolysis activities of recombinant mouse and human ABHD12 in transfected HEK293T cell lysates with IC50 of 30-90 nM. |
