| Cat. No. |
Product Name |
Information |
| PC-21686 |
BBO-8956
KRAS G12C inhibitor
|
BBO-8956 is a highly potent, covalent inhibitor of GTP-KRAS G12C, BBO-8956 is effective against both GDP and GTP-bound KRAS G12C. |
| PC-21640 |
ASP6918
KRAS G12C inhibitor
|
ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells. |
| PC-21604 |
Kobe2602
Ras inhibitor
|
Kobe2602 is a small-molecule Ras inhibitor that display antitumor activity by interfering with Ras·GTP-effector interaction, inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 149 uM. |
| PC-21544 |
KRAS G13D inhibitor 41
KRAS G13D inhibitor
|
KRAS G13D inhibitor 41 is a potent, selective KRAS G13D inhibitor with IC50 of 0.41 nM, 29-fold selective over WT KRAS. |
| PC-21543 |
K-Ras G12C inhibitor 6
KRAS G12C inhibitor
|
K-Ras(G12C) inhibitor 6 is a potent, irreversible, allosteric inhibitor of the K-Ras(G12C). |
| PC-21132 |
ACA22
KRAS inhibitor
|
ACA22 is a small molecule KRAS inhibitor, inhibits KRAS-mediated signal transduction in cells expressing wild type (WT) and G12D mutant KRAS. |
| PC-20958 |
AZD4747
KRAS G12C inhibitor
|
AZD4747 (AZD-4747) is a highly potent, selective, covalent and brain-penetrant inhibitor of KRAS G12C with IC50 of 15 nM. |
| PC-20884 |
NRAS-G4 inhibitor 18
NRAS-G4 inhibitor
|
NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM. |
| PC-20692 |
ACA-14
KRAS inhibitor
|
ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates. |
| PC-72503 |
K-tetracosapeptide
KARATE inhibitor
|
K-tetracosapeptide (K-TC) is a peptide of 24 amino acids corresponding to the helix a5 in KRAS4B, potent inhibitor of KARATE (KRAS4B-RHOA-mTORC2 Ensemble), specifically targets the KRAS4B-RHOA interaction. |
| PC-72502 |
TAT-K-tetracosapeptide
KARATE inhibitor
|
TAT-K-tetracosapeptide is K-tetracosapeptide fused to a cell-permeable TAT peptide, K-tetracosapeptide (K-TC) is a peptide of 24 amino acids corresponding to the helix a5 in KRAS4B, potent inhibitor of KARATE. |
| PC-36140 |
KRAS inhibitor 11
|
KRAS inhibitor 11 is a first-in-class, high-affinity, noncovalent allosteric KRAS inhibitor, disrupts KRAS-Raf interaction with Kd of 1.2 uM. |
