| Cat. No. |
Product Name |
Information |
| PC-24267 |
SOF-436
Ras inhibitor
|
SOF-436 is a small molecule covalent KRAS inhibitor with IC50 of 60 uM in nucleotide exchange assays, inhibits KRAS nucleotide exchange by guanine exchange factor SOS1 and the binding of KRAS to effector protein RAF. |
| PC-24256 |
(RS)-G12Di-1
KRAS-G12D inhibitor
|
(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D. |
| PC-24185 |
Sosimerasib
Ras inhibitor
|
Sosimerasib is a potent, selective inhibitor of KRAS. |
| PC-23931 |
ISM061-022
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor with IC50 values in the micromolar range, shows selectivity toward certain KRAS mutants. |
| PC-23930 |
ISM061-018-2
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor, exhibits substantial binding affinity to KRAS-G12D with SPR Kd of 1.4 uM, exhibits broad activity across KRAS mutants. |
| PC-23830 |
Dual SOS1 and SOS2 binder 1
SOS1/SOS2 binder
|
Dual SOS1 and SOS2 binder 1 is a dual SOS1 and SOS2 binder. |
| PC-23829 |
SOS2 binder 1
SOS2 binder
|
SOS2 binder 1 is a selective quinazoline-based compound that binds to the catalytic site of SOS2 with SPR KD of 4.6 uM, shows no binding to SOS1 up 200 uM. |
| PC-23776 |
INCB159020
KRAS G12D inhibitor
|
INCB159020 is a potent, selective KRAS G12D inhibitor with SPR binding Kd of 22 nM, IC50 of 33 nM in HTRF pERK cell assays. |
| PC-22872 |
KRAS G12C inhibitor 143D
KRAS G12C inhibitor
|
143D is a highly potent and selective, BBB-permeable KRAS G12C inhibitor, inhibits the binding of KRASG12C and SOS1 with IC50 of 21.1 nM. |
| PC-22827 |
LY3499446 mesylate
KRAS G12C inhibitor
|
LY3499446 mesylate is a potent, selective inhibitor of KRAS G12C. |
| PC-22826 |
LY3499446
KRAS G12C inhibitor
|
LY3499446 is a potent, selective inhibitor of KRAS G12C. |
| PC-22825 |
VT204
KRAS G12C inhibitor
|
VT204 is a small molecule inhibitor of KRAS G12C, effectively suppresses cell proliferation in NCI-H358 cells at 8 uM. |
