| Cat. No. |
Product Name |
Information |
| PC-24580 |
KRAS4b inhibitor Compound 3
KRAS4b inhibitor
|
KRAS4b inhibitor Compound 3 is a specific small molecule covalent modifier of canonical RAS isoform KRAS4b CaaX-box cysteine (C185), prevents its posttranslational processing and subsequent membrane attachment. |
| PC-24579 |
KRAS4b inhibitor Compound 2
KRAS4b inhibitor
|
SMDC994566 (KRAS4b inhibitor Compound 2) is a specific small molecule covalent modifier of canonical RAS isoform KRAS4b CaaX-box cysteine (C185), decreases proliferation and KRAS protein level in KRAS-dependent MEF cells. |
| PC-24267 |
SOF-436
Ras inhibitor
|
SOF-436 is a small molecule covalent KRAS inhibitor with IC50 of 60 uM in nucleotide exchange assays, inhibits KRAS nucleotide exchange by guanine exchange factor SOS1 and the binding of KRAS to effector protein RAF. |
| PC-24256 |
(RS)-G12Di-1
KRAS-G12D inhibitor
|
(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D. |
| PC-24185 |
Sosimerasib
Ras inhibitor
|
Sosimerasib is a potent, selective inhibitor of KRAS. |
| PC-23931 |
ISM061-022
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor with IC50 values in the micromolar range, shows selectivity toward certain KRAS mutants. |
| PC-23930 |
ISM061-018-2
Ras inhibitor
|
ISM061-018-2 is a potential pan-Ras inhibitor, exhibits substantial binding affinity to KRAS-G12D with SPR Kd of 1.4 uM, exhibits broad activity across KRAS mutants. |
| PC-23830 |
Dual SOS1 and SOS2 binder 1
SOS1/SOS2 binder
|
Dual SOS1 and SOS2 binder 1 is a dual SOS1 and SOS2 binder. |
| PC-23829 |
SOS2 binder 1
SOS2 binder
|
SOS2 binder 1 is a selective quinazoline-based compound that binds to the catalytic site of SOS2 with SPR KD of 4.6 uM, shows no binding to SOS1 up 200 uM. |
| PC-23776 |
INCB159020
KRAS G12D inhibitor
|
INCB159020 is a potent, selective KRAS G12D inhibitor with SPR binding Kd of 22 nM, IC50 of 33 nM in HTRF pERK cell assays. |
| PC-23212 |
ADT-1004
Ras inhibitor
|
ADT-1004 is an orally bioavailable prodrug of ADT-007, potent, selective pan-RAS inhibitor, selectively inhibits PDAC cells with mutant KRAS, does not impact the growth of tumors from RAS WT PDAC cells. |
| PC-22872 |
KRAS G12C inhibitor 143D
KRAS G12C inhibitor
|
143D is a highly potent and selective, BBB-permeable KRAS G12C inhibitor, inhibits the binding of KRASG12C and SOS1 with IC50 of 21.1 nM. |
