| Cat. No. |
Product Name |
Information |
| PC-35391 |
SOS1 activator 17
|
SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro. |
| PC-43022 |
6H05 trifluoroacetate
|
6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C), an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors.. |
| PC-43021 |
6H05
|
6H05 is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C), an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors.. |
| PC-62036 |
Lanperisone
|
Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion. |
| PC-61995 |
PDEδ-IN-99
|
PDEδ-IN-99 is a novel potent K-Ras-PDEδ inhibitor that binds to the farnesyl binding pocket of PDEδ with Kd of 8±4 nM.. |
| PC-70353 |
SRJ-23
|
A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation. |
| PC-61203 |
KRAS G12C inhibitor 1
|
A potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.. |
| PC-61202 |
1-AM
|
A potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.. |
| PC-61155 |
PDE6δ inhibitor 8
|
A novel selective small molecule inhibitor of PDE6δ/KRas interaction with Kd of 358 pM.. |
| PC-45536 |
K-Ras G12C-IN-12
|
An allosteric inhibitor of oncogenic K-Ras(G12C) with EC50 of 0.32 uM in H1792 cells. |
| PC-45478 |
K-Ras G12C-IN-3
|
A novel and irreversible inhibitor of mutant K-ras G12C.. |
| PC-45477 |
K-Ras G12C-IN-2
|
A novel and irreversible inhibitor of mutant K-ras G12C.. |
