| Cat. No. |
Product Name |
Information |
| PC-25960 |
PDE6δ-IN-2
PDEδ inhibitor
|
PDE6δ-IN-2 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells. |
| PC-25959 |
PDE6δ-IN-1
PDEδ inhibitor
|
PDE6δ-IN-1 is a potent, small molecule PDE6δ (PDE6delta, PDE6D) inhibitor with KD of <30 nM in displacement assays, inibits binding of PDE6δ to farnesylated Ras proteins and inhibits oncogenic Ras signaling in cells. |
| PC-25585 |
C4-180
RALGEF inhibitor
|
C4-180 is a potent, specific small molecule pan-RALGEF (Ras-like small GTPases exchange factors) inhibitor, specifically inhbits RAL but not MAPK/AKT signaling, impairs the interaction of RALGEFs with RAS. |
| PC-25521 |
SHY-867
Ras inhibitor
|
SHY-867 (SHY867) is a potent, non-covalent small molecule inhibitor of pan-Ras superfamily, competes with GTP binding to K-Ras WT, the G12D, G12C and Q61H mutants, as well as Rac-1 and Rho-A, with IC50 values of 1.25-5.0 uM. |
| PC-25520 |
SHY-855
Ras inhibitor
|
SHY-855 (SHY855) is a potent, non-covalent small molecule inhibitor of pan-Ras superfamily, competes with GTP binding to K-Ras WT, the G12D, G12C and Q61H mutants, as well as Rac-1 and Rho-A, with IC50 values of 2.5-5 uM. |
| PC-25265 |
MCB-294
KRAS inhibitor
|
MCB-294 is a potent, selective, dual-state pan-KRAS inhibitor capable of binding both the active (GTP-bound) and inactive (GDP-bound) forms of KRAS, effectively inactivates both wild-type KRAS and multiple KRAS mutants. |
| PC-24740 |
ARS-2102
KRAS G12C inhibitor
|
ARS-2102 is a potent, selective, covalent KRAS G12C inhibitor. |
| PC-24680 |
KRAS inhibitor-10
KRAS inhibitor
|
KRAS inhibitor-10 is a potent, selective and orally active inhibitor of RAS proteins,d particularly KRAS proteins. |
| PC-24666 |
AZD0022
KRAS G12D inhibitor
|
AZD0022 is a potent, selective and orally bioavailable inhibitor of KRAS G12D. |
| PC-24581 |
K-RAS4B inhibitor Cmpd2
KRAS4b inhibitor
|
KRAS4B inhibitor Cmpd2 is a specific inhibitor of K-RAS4B, inhibtis the KRAS activation of BRAF with IC50 of 0.8 uM in coupled assays, and BLI Kd of <1 uM prenylated K-RAS4B in the presence of PS. |
| PC-24580 |
KRAS4b inhibitor Compound 3
KRAS4b inhibitor
|
KRAS4b inhibitor Compound 3 is a specific small molecule covalent modifier of canonical RAS isoform KRAS4b CaaX-box cysteine (C185), prevents its posttranslational processing and subsequent membrane attachment. |
| PC-24579 |
KRAS4b inhibitor Compound 2
KRAS4b inhibitor
|
SMDC994566 (KRAS4b inhibitor Compound 2) is a specific small molecule covalent modifier of canonical RAS isoform KRAS4b CaaX-box cysteine (C185), decreases proliferation and KRAS protein level in KRAS-dependent MEF cells. |
