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Cat. No. Product Name Information
PC-72978

PHT-7.3

Cnksr1 (Cnk1) inhibitor

PHT-7.3 (Cnksr1 (Cnk1) inhibitor PHT-7.3) is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM).
PC-72963

KRA-533

KRAS agonist

KRA-533 (NSC112533, KRA533) is a small molecule KRAS agonist that binds the GTP/GDP-binding pocket of KRAS.
PC-72958

ASP2453

KRAS G12C inhibitor

ASP2453 (ASP-2453) is a novel potent, selective and covalent KRAS G12C inhibitor, inhibits SOS-mediated interaction between KRAS G12C and Raf with IC50 of 40 nM.
PC-72897

JDQ443

KRAS G12C inhibitor

JDQ443 (Opnurasib, NVP-JDQ443) is a potent, mutant-selective, covalent KRAS G12C inhibitor.
PC-72331

MRTX1133

KRAS G12D inhibitor

MRTX-1133 (MRTX1133) is a potent, selective and noncovalent inhibitor KRAS G12D with SPR Kd of 0.2 nM, AlphaLISA IC50 of 5 nM.
PC-72313

LY-3537982

KRAS-G12C inhibitor

LY-3537982 (LY3537982) is a highly selective and potent KRAS-G12C inhibitor, selectively inhibits growth of KRAS G12C mutant cells (IC50=1-60 nM).
PC-72227

MRTX849

KRAS G12C inhibitor

MRTX849 (Adagrasib, MRTX-849) is a potent, selective, and covalent KRAS G12C inhibitor, inhibits KRAS-dependent signaling.
PC-38330

Ral inhibitor 1

RalB inhibitor

Ral inhibitor 1 is a covalent inhibitor of RalB (Ras-like GTPase) activation, inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral GTPase, selectively inhibits Ral over Ras.
PC-38329

KAL-21404358

K-Ras(G12D) inhibitor

KAL-21404358 (KAL21404358) is a small-molecule, allosteric inhibitor of K-Ras(G12D), binds to K-Ras(G12D) P110 site with KD of 88 uM in MST assay.
PC-38327

K-Ras G12D inhibitor KS-58

K-Ras G12D inhibitor KS-58 is the first K-Ras(G12D) selective, bicyclic peptide inhibitor with binding Ki of 22 nM.
PC-38298

ML210

GPX4 inhibitor

ML210 (CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS.
PC-38296

BI-3406

SOS1-KRAS inhibitor

BI-3406 (BI 3406) is a highly potent and selective SOS1-KRAS interaction inhibitor with IC50 of 5 nM, binds to the catalytic domain of SOS1 with Kd of 9.7 nM.

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