Cat. No. |
Product Name |
Information |
PC-72978 |
PHT-7.3
Cnksr1 (Cnk1) inhibitor
|
PHT-7.3 (Cnksr1 (Cnk1) inhibitor PHT-7.3) is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). |
PC-72963 |
KRA-533
KRAS agonist
|
KRA-533 (NSC112533, KRA533) is a small molecule KRAS agonist that binds the GTP/GDP-binding pocket of KRAS. |
PC-72958 |
ASP2453
KRAS G12C inhibitor
|
ASP2453 (ASP-2453) is a novel potent, selective and covalent KRAS G12C inhibitor, inhibits SOS-mediated interaction between KRAS G12C and Raf with IC50 of 40 nM. |
PC-72897 |
JDQ443
KRAS G12C inhibitor
|
JDQ443 (Opnurasib, NVP-JDQ443) is a potent, mutant-selective, covalent KRAS G12C inhibitor. |
PC-72331 |
MRTX1133
KRAS G12D inhibitor
|
MRTX-1133 (MRTX1133) is a potent, selective and noncovalent inhibitor KRAS G12D with SPR Kd of 0.2 nM, AlphaLISA IC50 of 5 nM. |
PC-72313 |
LY-3537982
KRAS-G12C inhibitor
|
LY-3537982 (LY3537982) is a highly selective and potent KRAS-G12C inhibitor, selectively inhibits growth of KRAS G12C mutant cells (IC50=1-60 nM). |
PC-72227 |
MRTX849
KRAS G12C inhibitor
|
MRTX849 (Adagrasib, MRTX-849) is a potent, selective, and covalent KRAS G12C inhibitor, inhibits KRAS-dependent signaling. |
PC-38330 |
Ral inhibitor 1
RalB inhibitor
|
Ral inhibitor 1 is a covalent inhibitor of RalB (Ras-like GTPase) activation, inhibits guanine exchange factor Rgl2-mediated nucleotide exchange of Ral GTPase, selectively inhibits Ral over Ras. |
PC-38329 |
KAL-21404358
K-Ras(G12D) inhibitor
|
KAL-21404358 (KAL21404358) is a small-molecule, allosteric inhibitor of K-Ras(G12D), binds to K-Ras(G12D) P110 site with KD of 88 uM in MST assay. |
PC-38327 |
K-Ras G12D inhibitor KS-58
|
K-Ras G12D inhibitor KS-58 is the first K-Ras(G12D) selective, bicyclic peptide inhibitor with binding Ki of 22 nM. |
PC-38298 |
ML210
GPX4 inhibitor
|
ML210 (CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS. |
PC-38296 |
BI-3406
SOS1-KRAS inhibitor
|
BI-3406 (BI 3406) is a highly potent and selective SOS1-KRAS interaction inhibitor with IC50 of 5 nM, binds to the catalytic domain of SOS1 with Kd of 9.7 nM. |