| Cat. No. |
Product Name |
Information |
| PC-22632 |
MK-1084
KRAS G12C inhibitor
|
Calderasib (MK-1084) is a potent, orally bioavailable and low-dose KRAS G12C covalent inhibitor with IC50 of 1.2 nM in in vitro guanine nucleotide exchange assay, and 9 nM in cell-based phospho-ERK1/2 assay with H358 cell line. |
| PC-22631 |
LUNA18
KRAS inhibitor
|
Paluratide (LUNA18) is a highly potent, 11-mer cyclic peptide inhibitor of KRAS with IC50 of <2 nM for KRAS G12D-SOS1 PPI, KD of 0.043 nM for KRAS G12C. |
| PC-22626 |
Glecirasib
KRAS G12C inhibitor
|
Glecirasib (JAB-21822) is a highly selective, covalent oral KRAS G12C inhibitor with IC50 of 1.6 nM (SOS1-mediated guanine nucleotide exchange, GDP- KRAS G12C) and IC50 of 7.3 nM in Phospho-ERK inhibition assay in NCI-H358 cells. |
| PC-22125 |
RMC-6236
Ras inhibitor
|
Daraxonrasib (RMC-6236) is a first-in-class broad-spectrum RAS (ON) multi-selective inhibits, inhibits active state of both mutant and wild-type KRAS, NRAS and HRAS variants. |
| PC-22123 |
BBO-8520
KRAS G12C inhibitor
|
BBO-8520 is a potent, selective and covalent inhibitor of KRAS G12C (ON), locks GTP-bound KRASG12C in the state 1 conformation resulting in rapid and complete blockade of effector binding. |
| PC-22112 |
RMC-7977
Ras inhibitor
|
RMC-7977 (RMC7977) is a potent, highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with Kd of 116 nM, 94.7 nM and 101 nM respectively, KRAS G12V Kd of 85 nM. |
| PC-21775 |
ADT-007
Ras inhibitor
|
ADT-007 (ADT007) is a potent, specific pan-RAS inhibitor, shows potential to circumvent resistance to mutant-specific KRAS inhibitors and activates antitumor immunity. |
| PC-21604 |
Kobe2602
Ras inhibitor
|
Kobe2602 is a small-molecule Ras inhibitor that display antitumor activity by interfering with Ras·GTP-effector interaction, inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 149 uM. |
| PC-21542 |
CSC01
KRAS G13D inhibitor
|
CSC01 (CSC057253844) is a small molecule inhibitor of oncogenic KRAS mutant G13D (KRAS-G13D). |
| PC-21263 |
ERAS-5024
KRAS G12D inhibitor
|
ERAS-5024 (ERAS5024) is a potent and selective KRAS G12D inhibitor with IC50 of 0.86 nM in RAS-RAF binding assays, inhibits ERK1/2 phosphorylation (pERK) formation with IC50 of 2.1 nM in AsPC-1 cell-based assays. |
| PC-21132 |
ACA22
KRAS inhibitor
|
ACA22 is a small molecule KRAS inhibitor, inhibits KRAS-mediated signal transduction in cells expressing wild type (WT) and G12D mutant KRAS. |
| PC-21063 |
RMC-4998
KRAS G12C inhibitor
|
RMC-4998 (RM-029) is a tricomplex inhibitor that targets the active state or GTP-bound state of KRAS G12C, selectively inhibits the proliferation of KRASG12C mutant cells with mean IC50 of 0.28 nM. |
