| Cat. No. |
Product Name |
Information |
| PC-21640 |
ASP6918
KRAS G12C inhibitor
|
ASP6918 (ASP 6918) is a highly potent, covalent KRAS G12C inhibitor with IC50 of 28 nM in cell-free assays, and pERK inhibition IC50 of 3.7 nM in NCI-H1373 cells. |
| PC-21604 |
Kobe2602
Ras inhibitor
|
Kobe2602 is a small-molecule Ras inhibitor that display antitumor activity by interfering with Ras·GTP-effector interaction, inhibits the binding of H-Ras⋅GTP to c-Raf-1 RBD with Ki of 149 uM. |
| PC-21544 |
KRAS G13D inhibitor 41
KRAS G13D inhibitor
|
KRAS G13D inhibitor 41 is a potent, selective KRAS G13D inhibitor with IC50 of 0.41 nM, 29-fold selective over WT KRAS. |
| PC-21543 |
K-Ras G12C inhibitor 6
KRAS G12C inhibitor
|
K-Ras(G12C) inhibitor 6 is a potent, irreversible, allosteric inhibitor of the K-Ras(G12C). |
| PC-20958 |
AZD4747
KRAS G12C inhibitor
|
AZD4747 (AZD-4747) is a highly potent, selective, covalent and brain-penetrant inhibitor of KRAS G12C with IC50 of 15 nM. |
| PC-20884 |
NRAS-G4 inhibitor 18
NRAS-G4 inhibitor
|
NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM. |
| PC-72503 |
K-tetracosapeptide
KARATE inhibitor
|
K-tetracosapeptide (K-TC) is a peptide of 24 amino acids corresponding to the helix a5 in KRAS4B, potent inhibitor of KARATE (KRAS4B-RHOA-mTORC2 Ensemble), specifically targets the KRAS4B-RHOA interaction. |
| PC-72502 |
TAT-K-tetracosapeptide
KARATE inhibitor
|
TAT-K-tetracosapeptide is K-tetracosapeptide fused to a cell-permeable TAT peptide, K-tetracosapeptide (K-TC) is a peptide of 24 amino acids corresponding to the helix a5 in KRAS4B, potent inhibitor of KARATE. |
| PC-36140 |
KRAS inhibitor 11
|
KRAS inhibitor 11 is a first-in-class, high-affinity, noncovalent allosteric KRAS inhibitor, disrupts KRAS-Raf interaction with Kd of 1.2 uM. |
| PC-62036 |
Lanperisone
|
Lanperisone (NK 433) is a centrally acting muscle relaxant that selectively kills of K-ras mutant cancer cells in a cell cycle-independent fashion. |
| PC-70353 |
SRJ-23
|
A novel semisynthetic derivative of andrographolide that directly target Ras to block the exchange of GDP for GTP and thus prevent Ras activation. |
| PC-61203 |
KRAS G12C inhibitor 1
|
A potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.. |
