| Cat. No. |
Product Name |
Information |
| PC-38298 |
ML210
GPX4 inhibitor
|
ML210 (CID 49766530) is a small-molecule probe that selectively kill cells induced to express mutant RAS. |
| PC-38296 |
BI-3406
SOS1-KRAS inhibitor
|
BI-3406 (BI 3406) is a highly potent and selective SOS1-KRAS interaction inhibitor with IC50 of 5 nM, binds to the catalytic domain of SOS1 with Kd of 9.7 nM. |
| PC-38293 |
VUBI1
SOS1 activator
|
VUBI1 (SOS1 agonist 1) is a potent activator of SOS1 which modulates the KRAS pathway, binds directly to SOS1 (Kd=44 nM). |
| PC-38152 |
IODVA1
Rac inhibitor
|
IODVA1 is a small molecule with cellular inhibitory activity against several transformed cell lines including Ras-driven cells, targets Rac activation and signaling instead of Ras. |
| PC-36062 |
ZT-12-037-01
|
ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 of 20.04 nM measured as percentage of NRAS phosphorylation. |
| PC-36030 |
BAY-293
SOS1 inhibitor
|
BAY-293 (BAY293, BAY 293) is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction with IC50 of 21 nM. |
| PC-35952 |
MRTX1257
KRAS G12C inhibitor
|
MRTX1257 (MRTX-1257, MRTX 1257) is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, inhibits KRAS dependent ERK-phosphorylation in the H358 cell with IC50 of 0.9 nM. |
| PC-35613 |
KBFM123
H-Ras inhibitor
|
KBFM123 (KBFM-123) is a small molecule, allosteric inhibitor of GTP-bound form of H-Ras, weakly inhibits the association of H-RasG12V-GppNHp with c-Raf-1 RBD (Kd=10-100 uM). |
| PC-35300 |
RasGRP3 ligand 96
RasGRP3 ligand
|
RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, showed 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively. |
| PC-63506 |
CMC2.24
Ras inhibitor
|
CMC2.24 (TRB-N0224) is a novel tricarbonylmethane agent that inhibits the Ras-RAF-MEK-ERK pathway, inhibits Ras activation in pancreatic cancer both in vitro and in vivo. |
| PC-62695 |
pan-Ras inhibitor 3144
Ras inhibitor
|
pan-Ras inhibitor 3144 (Compound 3144) is a multivalent small-molecule, pan-RAS inhibitor with Kd of 4.7/17/6.6/3.7 uM for KRAS G12D/KRAS wt/HRAS/NRAS respectively. |
| PC-62496 |
ARS-1323
KRAS G12C inhibitor
|
ARS1323 is a racemic mixture of ARS-1620/R-atropisomer, ARS-1620 is a potent, specific and covalent KRAS G12C inhibitor with >10-fold improved potency over the initial ARS-853.. |
