Cat. No. |
Product Name |
Information |
PC-21542 |
CSC01
KRAS G13D inhibitor
|
CSC01 is a small molecule inhibitor of oncogenic KRAS mutant G13D (KRAS-G13D). |
PC-21375 |
AVJ16
Igf2bp1 inhibitor
|
AVJ16 is a specific and potent IGF2BP1 inhibitor, inhibits H1299 wound healing with IC50 of 0.7 uM, interacts with recombinant IGF2BP1 protein with KD of 1.4 uM in MST assays. |
PC-21263 |
ERAS-5024
KRAS G12D inhibitor
|
ERAS-5024 (ERAS5024) is a potent and selective KRAS G12D inhibitor with IC50 of 0.86 nM in RAS-RAF binding assays, inhibits ERK1/2 phosphorylation (pERK) formation with IC50 of 2.1 nM in AsPC-1 cell-based assays. |
PC-21132 |
ACA22
KRAS inhibitor
|
ACA22 is a small molecule KRAS inhibitor, inhibits KRAS-mediated signal transduction in cells expressing wild type (WT) and G12D mutant KRAS. |
PC-21063 |
RMC-4998
KRAS G12C inhibitor
|
RMC-4998 (RMC4998) is a tricomplex inhibitor that targets the active state or GTP-bound state of KRAS G12C, selectively inhibits the proliferation of KRASG12C mutant cells with mean IC50 of 0.28 nM. |
PC-20958 |
AZD4747
KRAS G12C inhibitor
|
AZD4747 (AZD-4747) is a highly potent, selective, covalent and brain-penetrant inhibitor of KRAS G12C with IC50 of 15 nM. |
PC-20884 |
NRAS-G4 inhibitor 18
NRAS-G4 inhibitor
|
NRAS-G4 inhibitor 18 is a specific small molecule inhibitor targeting G4 in the 5′-UTR of the NRAS mRNA, binds to a G4 in the NRAS mRNA with KD value of 0.25 uM. |
PC-20692 |
ACA-14
KRAS inhibitor
|
ACA-14 is a small molecule direct inhibitor of KRAS, impedes the interaction of KRAS with its effector Raf and reduces both intrinsic and SOS-mediated nucleotide exchange rates. |
PC-20553 |
Igf2bp1 inhibitor 7773
Igf2bp1 inhibitor
|
Igf2bp1 inhibitor 7773 is a specific small molecule inhibitor of Igf2bp1, binds to RNA binding domains of Igf2bp1, inhibits Igf2bp1 binding of Kras 6 RNA with IC50 of 30 uM. |
PC-20251 |
Lonafranib
Ras inhibitor
|
Lonafranib (SCH 66336) is a potent, selective and orally active farnesyl protein transferase (FPT) inhibitor with IC50 of 1.9 nM, 5.2 nM and 2.8 nM for H-ras, K-ras-4B and N-ras, respectively. |
PC-20249 |
SCH53239
Ras inhibitor
|
SCH-53239 (SCH53239) is a small molecule inhibitor of Ras nucleotide exchange with IC50 of 0.5 uM, bind competitively with GDP in the nucleotide binding site of the Ras protein. |
PC-20037 |
Fulzerasib
Ras inhibitor
|
Fulzerasib is a potent selective inhibitor of KRAS gene mutation. |