| Cat. No. |
Product Name |
Information |
| PC-61152 |
Deltazinone 1
PDE6D-RAS inhibitor
|
Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM. |
| PC-60886 |
UC-857993
SOS1-Ras inhibitor
|
UC-857993 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction. |
| PC-60885 |
UC-773587
SOS1-Ras inhibitor
|
UC-773587 is a small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction. |
| PC-70154 |
ML162
GPX4 inhibitor
|
ML162 (ML-162) is a small-molecule, covalent glutathione peroxidase 4 (GPX4) inhibitor, selectively kills cells induced to express mutant RAS, inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM. |
| PC-45721 |
ML-098
Ras activator
|
ML-098 (CID-7345532) is a small molecule pan activator families of Ras-related GTPases (EC50=77-588 nM for Rab7, Rab-2A, Cdc42, Rac1). |
| PC-45673 |
ARS-853
KRAS G12C inhibitor
|
ARS-853 (ARS853) is a mutant-specific, covalent inhibitor of KRAS G12C with IC50 of 2.5 uM. |
| PC-45476 |
K-Ras G12C-IN-1
KRAS G12C inhibitor
|
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C. |
| PC-24740 |
ARS-2102
KRAS G12C inhibitor
|
ARS-2102 is a potent, selective, covalent KRAS G12C inhibitor. |
| PC-24680 |
KRAS inhibitor-10
KRAS inhibitor
|
KRAS inhibitor-10 is a potent, selective and orally active inhibitor of RAS proteins,d particularly KRAS proteins. |
| PC-24666 |
AZD0022
KRAS G12D inhibitor
|
AZD0022 is a potent, selective and orally bioavailable inhibitor of KRAS G12D. |
| PC-24662 |
AMG410
KRAS inhibitor
|
AMG410 is a potent, non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D,> 100-fold selectivity against both HRAS and NRAS. |
| PC-24581 |
K-RAS4B inhibitor Cmpd2
KRAS4b inhibitor
|
KRAS4B inhibitor Cmpd2 is a specific inhibitor of K-RAS4B, inhibtis the KRAS activation of BRAF with IC50 of 0.8 uM in coupled assays, and BLI Kd of <1 uM prenylated K-RAS4B in the presence of PS. |
