| Cat. No. |
Product Name |
Information |
| PC-72772 |
SIRT3 inhibitor 8
SIRT3 inhibitor
|
SIRT3 inhibitor 8 is a SIRT3 selective inhibitor with IC50 of 6 uM, 6.8- and 5.3-fold selectivity for SIRT3 versus SIRT1 and SIRT2. |
| PC-72767 |
SIRT5 inhibitor 49
SIRT5 inhibitor
|
SIRT5 inhibitor 49 (Sirt5-i) is a potent and specific SIRT5 inhibitor with IC50 of 0.11 uM. |
| PC-72766 |
SIRT5 inhibitor 32
SIRT5 inhibitor
|
SIRT5 inhibitor 32 is an efficient, cellularly active small molecule that targets SIRT5. |
| PC-36070 |
JH-T4
|
JH-T4 is a potent small molecule SIRT2 inhibitor with IC50 of 0.3 uM (sirtuin deacylation activity), increase intracellular K-Ras4a lysine fatty acylation. |
| PC-35876 |
SirT1 enhancer A03
|
SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer, increases the levels of the neuroprotective enzyme SirT1 while not affecting levels of neurotoxic SirT2 in vitro in ApoE4-transfected cells (EC50=2 uM). |
| PC-35524 |
SRTCX1003
|
SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay. |
| PC-35523 |
SRTCX1002
|
SRTCX1002 (SRTCX-1002) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.4 uM, enhances deacetylation of cellular p65 protein with IC50 of 0.84 uM in cellular p65 acetylation assay. |
| PC-43528 |
Tenovin-1
|
Tenovin-1 (Tenovin1) is a small molecules that activate p53 and decreases tumor growth through inhibition of the protein-deacetylating activities of SirT1 and SirT2. |
| PC-42347 |
Thiomyristoyl
|
Thiomyristoyl is a highly selective and potent SIRT2 inhibitor with IC50 of 28 nM, displays no significant activity against SIRT1/3/5/6/7 (Ic50>100 uM). |
| PC-63006 |
SRT 3025
|
SRT3025 is a potent, orallu actuve SIRT1 activator that activates wild-type Sirt1 protein, but not the Sirt1 mutant E230K. |
| PC-61906 |
MIND-4
|
MIND-4 is a novel potent, selective, non-competitive SIRT2 deacetylase inhibitor with IC50 of 1.2 uM, Ki of 2.1 uM, and also is an inducer of the NRF2 pathway. |
| PC-60825 |
YK-3-237
|
A novel small molecule sirtuin-1 (SIRT1) activator that reduces acetylation of mutant 53 and exhibits anti-proliferative effects against TNBC cells carrying mutant p53. |
