| Cat. No. |
Product Name |
Information |
| PC-26525 |
S3226
NHE3 inhibitor
|
S3226 is a potent, selective Na+/H+ exchanger subtype 3 (NHE3, SLC9A3) inhibitor with IC50 of 0.02 uM (hNHE3), shows >100-fold selectivity over hNHE1 and rbNHE2. |
| PC-26470 |
AM-2099
NaV1.7 inhibitor
|
AM-2099 is a potent, selective inhibitor of voltage-gated sodium channel NaV1.7 with IC50 of 0.16 uM (hNaV1.7), with no actiivity against hNaV1.5. |
| PC-26048 |
Eleclazine
I(Na,late) inhibitor
|
Eleclazine (GS6615) hydrochloride is a potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3), hypertrophic cardiomyopathy (HCM), and ventricular tachycardia–ventricular fibrillation (VT–VF). |
| PC-25144 |
GSK3β-Nav1.6 inhibitor 1063
GSK3β/Nav1.6 inhibitor
|
GSK3β-Nav1.6 inhibitor 1063 is a brain-penetrant small molecule that selectively disrupts GSK3β/Nav1.6 complex formation (IC50=26.2 uM) and inhibits Nav1.6 currents in an isoform-specific manner. |
| PC-25089 |
Repunapanor
NHE3 inhibitor
|
Repunapanor is a potent, selective Na+/H+ exchanger 3 (NHE3) inhibitor. |
| PC-25070 |
ZL192
FGF13/Nav1.7 inhibitor
|
ZL192 is a small molecule FGF13 ligand / activator and a positive modulator of FGF13/Nav1.7 complex, stabilizes FGF13/Nav1.7 CTD assembly with EC50 of 28 uM, sensitizes Na+ currents in hIPSC-derived sensory neurons. |
| PC-25010 |
NaV1.6 inhibitor Compound 103
NaV1.6 inhibitor
|
NaV1.6 inhibitor Compound 103 is a potent, selective voltage-gated sodium channel NaV1.6 inhibitor with IC50 of 61 nM, >400-fold selective over NaV1.1 and NaV1.5. |
| PC-24889 |
Methocarbamol
Nav1.4 inhibitor
|
Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channe, reversibly affects voltage dependence of inactivation of Nav1.4 channel. |
| PC-24199 |
Zilvetrigine
Sodium channel inhibitor
|
Zilvetrigine is a potent, selective sodium channel inhibitor with potential for treatment of pain. |
| PC-24162 |
Olisutrigine bromide
Sodium channel blocker
|
Olisutrigine bromide (EN3427) is a novel permanently charged cationic sodium channel blocker, produces effective and long-lasting analgesia in rodent pain models. |
| PC-24070 |
E0199
NaV inhibitor, Kv7 activator
|
E0199 is a dual-targeting inhibitor of NaV1.7, NaV1.8, and NaV1.9 and activator of KV7 channels with IC50 of 0.52 uM (NaV1.7), 0.24 uM (NaV1.8), 0.16 uM (NaV1.9), and EC50 of 0.5 uM/12.78 nM/0.19 uM for KV7.2, KV7.2/7.3 and KV7.4 channels. |
| PC-24050 |
Nav1.7 inhibitor WN2-R
Nav1.7 inhibitor
|
Nav1.7 inhibitor WN2-R is a novel potent, selective Nav1.7 antagonist with IC50 of 24.7 nM within the VSDIV pocket of Nav1.7. |
