| Cat. No. |
Product Name |
Information |
| PC-72208 |
SSCI-1
Nav1.7 inhibitor
|
SSCI-1 is a highly potent, selective NaV1.7 inhibitor with IC50 of 27 and 82 nM on human and rhesus Nav1.7 channels, respectively. |
| PC-72207 |
NaV1.7 inhibitor 51
Nav1.7 inhibitor
|
NaV1.7 inhibitor 51 is a highly potent, selective, orally active NaV1.7 inhibitor with IC50 of 10.7 nM in FLIPR membrane potential assay, no significant activity against NaV1.5 (IC50>10 uM). |
| PC-72206 |
ProTx-II
NaV1.7 inhibitor
|
ProTx II (Protoxin II) is a selective NaV1.7 channel blocker with 100-fold selectivity over other sodium channel subtypes. |
| PC-72205 |
DA-0218
Nav1.7 inhibitor
|
DA-0218 (DA0218) is a novel potent, selective Nav1.7 inhibitor, inhibits sodium currents in Nav1.7-expressing human embryonic kidney 293 cells with IC50 of 0.74 uM. |
| PC-36160 |
GNE-616
|
GNE-616 (GNE616) is a highly potent, metabolically stable, subtype selective inhibitor of Nav1.7 with Ki of 0.79 nM (hNav1.7). |
| PC-36104 |
Voluloride
|
Voluloride is a conjunctival epithelial cell sodium channel (ENaC) blocker.. |
| PC-35885 |
PF-06305591
|
PF-06305591 (PF06305591) is a potent, highly selective selective NaV1.8 blocker with IC50 of 15 nM, displays no significant activity against other sodium channel subtypes, K+ channels and Ca2+ channels. |
| PC-35154 |
PF-06526290
|
PF-06526290 is a potent, selective Nav1.3 inhibitor with IC50 of 5.1 uM, interact with the Domain 4 voltage sensor domain (D4 VSD and shows no activity for Nav1.7.. |
| PC-35118 |
VGSC blocker 4
|
VGSC blocker 4 is a potent, small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5), blocks INa peak currents 25% at 1 uM. |
| PC-35117 |
VGSC blocker 1
|
VGSC blocker 1 is a potent, small molecule blocker of neonatal isoform of the VGSC subtype, Nav1.5 (nNav1.5), blocks INa peak currents 34.9% at 1 uM. |
| PC-35103 |
GNE-131
|
GNE-131 is a potent, selective inhibitor of sodium channel NaV1.7 with IC50 of 3 nM, >80-fold selectivity over the cardiac sodium channel NaV1.5. |
| PC-35055 |
Rimeporide
|
Rimeporide (EMD87580) is a potent, selective sodium hydrogen exchanger NHE1 inhibitor, show promise as potential therapeutic agents for the treatment of heart failure.. |
