| Cat. No. |
Product Name |
Information |
| PC-35086 |
PF-06869206
|
PF-06869206 (PF06869206) is a novel potent, selective, orally bioavailable inhibitor of Sodium-Phosphate Cotransporter NaPi2a (SLC34A1) with IC50 of 380 nM. |
| PC-35052 |
Cariporide
|
Cariporide (HOE642) is a potent, selective sodium-hydrogen exchange subtype 1 (NHE1) inhibitor with IC50 of 50 nM, shows little to no activity against NHE3 and NHE2 (IC50=3 and 10 uM). |
| PC-43215 |
CNV1014802
Nav1.7 inhibitor
|
CNV1014802 (GSK-1014802, Raxatrigine, Vixotrigine, BIIB074) is a potent, selective Nav1.7 sodium channel blocker, shows analgesic effects and potential in the treatment of cognitive symptoms of schizophrenia in vivo. |
| PC-43094 |
Tetrodotoxin
Sodium channel blocker
|
Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6. |
| PC-63166 |
PF-05089771
Nav1.7 inhibitor
|
PF-05089771 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 11 nM, >1,000-fold selectivity over Nav1.3, 1.4 and Nav1.5, 1.8. |
| PC-63147 |
Tenapanor
|
Tenapanor (AZD-1722, RDX5791) is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively |
| PC-63146 |
Tenapanor hydrochloride
|
Tenapanor (AZD-1722;RDX5791) is a potent, selective inhibitor of the Na+/H+ exchanger 3 (NHE3) with IC50 of 5 and 10 nM for human and rat NHE3, respectively. |
| PC-62325 |
GNE-0439
Nav1.7 inhibitor
|
GNE-0439 is a novel potent, selective inhibitor of Nav1.7 channel with IC50 of 0.34 uM, shows high selectivity over Nav1.5 (IC50=38.3 uM). |
| PC-62324 |
GX-936
|
GX-936 (PF 05196233) is a potent Nav1.7 inhibitor that binds to the activated state of voltage-sensor domain IV (VSD4), exhibits robust inhibition of the 1KαPMTX-evoked N1742K response with IC50 of 40 nM. |
| PC-62323 |
GX-674
Nav1.7 inhibitor
|
GX-674 is a potent, selective Nav1.7 inhibitor with IC50 of 0.1 nM. |
| PC-61869 |
XEN-402
|
XEN-402 (Funapide,TV-45070) is a potent and selective, orally available sodium channel Nav1.7 and Nav1.8 blocker for treatment of pain. |
| PC-60629 |
AMG 8379
NaV1.7 inhibitor
|
AMG 8379 (AMG-8379, AMG8379) is a potent and selective voltage-gated sodium channel Nav1.7 antaognist with IC50 of 8.5 nM. |
