| Cat. No. |
Product Name |
Information |
| PC-21678 |
LTGO-33
NaV1.8 inhibitor
|
LTGO-33 is a potent, selective inhibitor of voltage-gated sodium channel NaV1.8 with IC50 of 44 nM (hNaV1.8), 600-fold selectivity against NaV1.1-NaV1.7 and NaV1.9. |
| PC-49611 |
A-887826
Nav 1.8 inhibitor
|
A-887826 (A 887826) is a potent and voltage-dependent Na(v)1.8 sodium channel blocker with IC50 of 11 nM (hNav1.8), potently blocks tetrodotoxin-resistant sodium (TTX-R Na(+)) currents (IC50=8 nM) from small diameter rat DRG neurons. |
| PC-49224 |
AM-0466
NaV1.7 inhibitor
|
AM-0464 (AM0464) is a highly potent, selective NaV1.7 inhibitor with IC50 of 21 nM, exhibits high levels of selectivity over other sodium channel isoforms (NaV1.5, IC50>30 uM). |
| PC-47037 |
QX-314 bromide
Sodium channel inhibitor
|
QX 314 bromide is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels, also inhibits calcium currents in hippocampal CA1 pyramidal neurons. |
| PC-47036 |
QX-314 chloride
Sodium channel blocker
|
QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels, also inhibits calcium currents in hippocampal CA1 pyramidal neurons. |
| PC-47030 |
BW-031 iodide
Nav1.7 inhibitor
|
BW-031 iodide is a potent cationic sodium channel inhibitor, inhibited Nav 1.7 (IC50=9.5 uM) and Nav 1.1 channels with approximately sixfold greater potency than QX-314. |
| PC-47029 |
BW-031 chloride
Nav1.7 inhibitor
|
BW-031 chloride is a potent cationic sodium channel inhibitor, inhibits Nav 1.7 (IC50=9.5 uM) and Nav 1.1 channels with approximately sixfold greater potency than QX-314. |
| PC-38662 |
ABBV-318
Nav1.7/ Nav1.8 blocker
|
ABBV-318 is a small molecule voltage-gated sodium channel Nav1.7/ Nav1.8 blocker with IC50 of 3.8 and 2.8 uM for hNav1.7 and hNav1.8 in FRET assays, respectively. |
| PC-38569 |
DPI 201-106
Na+ channel opener
|
DPI 201-106 (SDZ 201106) is a positive inotropic agent that prolongs the open state of cardiac voltage-gated Na+ channels. |
| PC-38398 |
Idrevloride
ENaC inhibitor
|
Idrevloride (P-1037) is a potent, selective epithelial sodium channel (ENaC) blocker with potential for the treatment of skin disorders. |
| PC-73408 |
Bliretrigine
Sodium Channel inhibitor
|
Bliretrigine is a sodium channel blocker with the effect of relieving pain. |
| PC-73335 |
ASIC1a inhibitor 5b
ASIC1a inhibitor
|
ASIC1a inhibitor 5b is a highly selective and potent ASIC1a inhibitor, inhibits proton-evoked ASIC1a currents with an apparent IC50 of 27 nM at pH 6.7. |
