| Cat. No. |
Product Name |
Information |
| PC-60163 |
ADX88178
mGluR4 modulator
|
ADX88178 (ADX88178) is a potent, selective, orally active mGluR4 positive allosteric modulator with EC50 of 4 and 9 nM for human and rat mGlu4, respectively. |
| PC-45900 |
LY-404039
|
A potent, slective agonist of mGlu2 and mGlu3 receptors with Ki of 149 nM and 92 nM, respectively. |
| PC-45568 |
LY354740
group 2 mGluR agonist
|
LY354740 (Eglumegad) is a potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM. |
| PC-45947 |
LY-341495
Group II mGluR antagonist
|
LY-341495 (LY341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively. |
| PC-22232 |
AZ12216052
mGluR8 PAM
|
AZ12216052 is potent, selective positive allosteric modulator of mGluR8, potentiates the effect of 300 nM glutamate with EC50 of 1.0 uM in [35S]GTPγS binding assays. |
| PC-22231 |
VU0361737
mGluR4 PAM
|
VU0361737 (ML128) is a potent, selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 240 nM and 110 nM for human and rat mGluR4 receptors, respectively. |
| PC-22230 |
VU0155041
mGluR4 PAM
|
VU0155041 is a potent, selective positive allosteric modulator of metabotropic glutamate receptor 4 (mGluR4) with EC50 of 798 and 693 nM at human and rat mGluR4, respectively. |
| PC-22229 |
(S)-3,4-DCPG
mGluR8 agonist
|
(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM). |
| PC-21049 |
MK-8768
mGluR2 modulator
|
MK-8768 (MK8768) is a potent, selective mGluR2 negative allosteric modulator (NAM) with IC50 of 9.6 nM, shows no activity against mGluR 1,3,4,5,6,8. |
| PC-20615 |
ADX71743
mGluR7 modulator
|
ADX71743 is a potent, selective and brain-penetrant mGluR7 negative allosteric modulator with EC50 of 63 and 88 nM for human and mouse mGluR7, respectively. |
| PC-20614 |
CVN636
mGluR7 agonist
|
CVN636 is a potent, selective, CNS penetrant and allosteric agonist of mGluR7 with EC50 of 7 and 2 nM for human and mouse mGluR7, respectively. |
| PC-20314 |
JNJ-42491293
mGlu2 ago-PAM
|
JNJ-42491293 (JNJ 42491293) is a potent, mGlu2-selective allosteric agonist and positive allosteric modulator (ago-PAM). |
