| Cat. No. |
Product Name |
Information |
| PC-61058 |
PF-06462894
|
A potent, subtype-selective mGluR5 negative allosteric modulator with Ki of 6.1 nM. |
| PC-60937 |
VU 6010572
|
A potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 245 nM. |
| PC-60822 |
TASP 0433864
|
A novel potent, selective mGluR2 positive allosteric modulator with EC50 of 199 and 206 nM for human and rat mGlu2, respectively, without exerting agonist activity. |
| PC-60820 |
VU0477573
|
A potent, selective, brain penetrant partial negative allosteric modulator of mGlu5 receptor with Ki of 14 nM, Ca assay IC50 of 32 nM. |
| PC-60818 |
LY 2812223
|
A highly potent, functionally selective mGlu2 receptor agonist with EC50 of 13.6 nM in GTPγS functional binding assay. |
| PC-60792 |
AZD 9272
|
A potent, selective, highly CNS-penetrant and orally available mGluR5 negative allosteric modulator Kd of 2.8 nM. |
| PC-60791 |
AZD 2066
|
A potent, selective, highly CNS-penetrant mGluR5 antagonist. |
| PC-60731 |
LY3027788
|
A orally active prodrug of LY3020371, which is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively. |
| PC-60730 |
LY3020371 hydrochloride
|
A potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, respectively. |
| PC-60513 |
Foliglurax hydrochloride
|
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
| PC-60512 |
Foliglurax
|
A potent, selective, brain-penetrant and orally bioavailable mGluR4 positive allosteric modulator with EC50 of 79 nM. |
| PC-60162 |
VU6005649
|
A potent, CNS penetrant, dual mGlu7/8 positive allosteric modulator with EC50 of 0.65/2.6 uM, respectively. |
