| Cat. No. |
Product Name |
Information |
| PC-49746 |
HTL14242
mGlu5 NAM
|
HTL14242 (HTL0014242) a potent, selective mGlu5 negative allosteric modulator (NAM) with pKi of 9.3 and pIC50 of 9.2, shows high selectivity within the metabotropic family of GPCRs. |
| PC-49593 |
VU6027459
mGlu7 PAM
|
VU6046980 is a potent, selective and CNS-penetrant mGlu7 positive allosteric modulator (PAM) with EC50 of 1.6 uM (rat mGlu7). |
| PC-38454 |
ML254
mGlu5 PAM
|
ML254 (VU0430644) is a potent, selective metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator with EC50 of 9.3 nM. |
| PC-35963 |
BMS-952048
|
BMS-952048 is a positive allosteric modulator of mGluR5 with EC50 of 10 nM.. |
| PC-35879 |
VU0652957
|
VU0652957 (VU2957, Valiglurax) is a potent, selective mGlu4 positive allosteric modulator (PAM) with EC50 of 64.6 nM in calcium mobilization human mGlu4/Gqi5 assays. |
| PC-35690 |
VU6001376
|
VU6001376 (VU 6001376, VU-6001376) is a potent, selective, positive allosteric modulator of mGlu4 with EC50 of 28 nM, 49% Glu Max, shows no activity against other 7 mGlu receptors. |
| PC-35487 |
VU0418506
|
VU0418506 (VU 0418506) is a potent and selective mGlu4 positive allosteric modulator (PAM) with EC50 of 68 nM (hmGlu4). |
| PC-43392 |
MTEP hydrochloride
|
MTEP hydrochloride is a potent, selective, non-competitive mGlu5 antagonist with IC50 of 5 nM and Ki of 16 nM. |
| PC-43360 |
ADX-47273
|
ADX-47273 is a potent and selective mGlu5 positive allosteric modulators (PAM) with with EC50 of 170 nM. |
| PC-63236 |
LY2794193
|
LY2794193 is a highly potent and selective mGlu3 receptor agonist with Ki of 0.93 nM and EC50 of 47 nM, >100-fold selectivity over mGlu2 receptor.. |
| PC-43079 |
Methoxy-PEPy
|
Methoxy-PEPy is a potent, selective mGlu5 receptor antagonist with IC50 of 1 nM. |
| PC-63181 |
AZD8529 mesylate
|
AZD8529 is a novel potent, selective mGluR2 positive allosteric modulator with EC50 of 195 nM, does not produce any positive allosteric modulator responses for mGluR1 and 3-8 subtypes. |
