| Cat. No. |
Product Name |
Information |
| PC-62953 |
VU-29
|
VU-29 (DPAP) is a potent, selective and allosteric potentiator of rat mGlu5 receptor with EC50 of 9 nM, displays >50-fold selectivity over mGlu1 and mGlu2 receptor (EC50=557 nM and 1.51 uM). |
| PC-62129 |
VU0422288
Group III mGluR modulator
|
VU0422288 is a potent, selective, CNS-penetrant pan-Group III mGlu positive allosteric modulator with IC50 of 110/146/130 nM for mGlu8/7/4, respectively, displays >30-fold selectivity over groups I and II mGlus (mGlu1/2/3/5/6). |
| PC-62120 |
ML353
mGlu5 modulator
|
ML353 (VU0478006) is a highly potent, selective, MPEP-site silent allosteric modulator of mGlu5 receptor with with sub-100 nM affinity. |
| PC-61612 |
LY-487379 hydrochloride
|
LY-487379 hydrochloride is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3. |
| PC-61611 |
LY-487379
|
LY-487379 is a potent, selective positive allosteric modulator of mGluR2 (EC50=0.27 uM) without activity at mGluR3. |
| PC-61513 |
JNJ-40411813
|
JNJ-40411813 is a novel potent positive allosteric modulator of mGlu2 with EC50 of 147 nM. |
| PC-61212 |
AMN 082 dihydrochloride
mGluR7 agonist
|
AMN 082 dihydrochloride (AMN082) is potent, selective, brain penetrant, orally acitve mGluR7 allosteric agonist, inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64 nM. |
| PC-61211 |
AMN 082
mGluR7 agonist
|
AMN 082 (AMN082) is a potent, selective mGluR7 allosteric agonist, inhibits forskolin-stimulated cAMP accumulation in mGluR7b CHO cells with EC50 of 64 nM. |
| PC-60939 |
VU 6001966
mGlu2 modulator
|
VU 6001966 is a potent and selective, CNS penetrant mGlu2 negative allosteric modulator with IC50 of 78 nM. |
| PC-60936 |
VU 0650786
mGlu3 modulator
|
VU 0650786 (VU0650786, VU-0650786) is a potent and selective, CNS penetrant mGlu3 negative allosteric modulator with IC50 of 392 nM, with no significant activity against other mGlus (IC50>10 uM). |
| PC-60697 |
mGlu5 PAM 4k
|
mGlu5 PAM 4k is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM. |
| PC-60696 |
JNJ-46778212
|
JNJ-46778212 (VU0409551) is a potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 260 nM |
