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Cat. No. Product Name CAS No. Information
PC-45693

Lumateperone tosylate

1187020-80-9 Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM); also shows affinity for D1; orally bioavailable and exhibits good antipsychotic efficacy in vivo.

Schizophrenia

Phase 3 Clinical

PC-42254

YL0919

1339058-04-6 An orally active, dual 5-HT1A agonist and selective serotonin reuptake inhibitor with Ki of 0.19 nM and IC50 of 1.78 nM, respectively; shows no affinity for dopamine receptors and others 5-HT receptors; inhibits forskolin-stimulated cAMP formation and 5-HT uptake in both rat cortical synaptosomes and recombinant cells; significantly reverses the depressive-like behaviors in chronically stressed rats.
PC-45233

Iloperidone hydrochloride

1299470-39-5 An atypical antipsychotic that exhibits high affinity to serotonin 5HT2A (Ki =5.6 nM), dopamine D2 (Ki=6.3 nM) and D3 (Ki=7.1 nM) and noradrenaline α1 receptors (Ki=0.36 nM), moderate affinity for D4 (25 nM), 5HT6 (43 nM), 5HT7 (22 nM), and low affinity for 5HT1A (168 nM), D1 and histamine H1 receptors; is used for the treatment of schizophrenia.

Schizophrenia

Approved

PC-45232

Iloperidone

133454-47-4 An atypical antipsychotic that exhibits high affinity to serotonin 5HT2A (Ki =5.6 nM), dopamine D2 (Ki=6.3 nM) and D3 (Ki=7.1 nM) and noradrenaline α1 receptors (Ki=0.36 nM), moderate affinity for D4 (25 nM), 5HT6 (43 nM), 5HT7 (22 nM), and low affinity for 5HT1A (168 nM), D1 and histamine H1 receptors; is used for the treatment of schizophrenia.

Schizophrenia

Approved

PC-42792

Risperidone mesylate

666179-96-0 An antipsychotic agent with serotonin-S2 and dopamine-D2 antagonistic properties; also has actions at several 5-HT receptor subtypes, adrenergic receptors and histamine H1 receptors.

Schizophrenia

Approved

PC-42791

Risperidone hydrochloride

666179-74-4 An antipsychotic agent with serotonin-S2 and dopamine-D2 antagonistic properties; also has actions at several 5-HT receptor subtypes, adrenergic receptors and histamine H1 receptors.

Schizophrenia

Approved

PC-42790

Risperidone

106266-06-2 An antipsychotic agent with serotonin-S2 and dopamine-D2 antagonistic properties; also has actions at several 5-HT receptor subtypes, adrenergic receptors and histamine H1 receptors.

Schizophrenia

Approved

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