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Cat. No. Product Name Information
PC-38717

UCSF678

5-HT5A agonist

UCSF678 is a potent, selective arrestin-biased partial agonist of 5-HT5A serotonin receptor with EC50 of 42 nM.
PC-38596

SB 224289 hydrochloride

5-HT1B antagonist

SB 224289 hydrochloride is a potent, selective 5-HT1B inverse agonist/antagonist with pKi value of 8.16, displays >75-fold selectivity over all other 5-HT receptors.
PC-73309

Vabicaserin

5-HT2C agonist

Vabicaserin (SCA-136) is a potent, selective 5-HT2C receptor full agonist with EC50 of 8 nM, Emax 100%.
PC-73307

Felcisetrag

5-HT4 agonist

Felcisetrag (TAK-954, TD-8954) is a highly selective and potent 5-HT4 receptor agonist with pKi of 9.4 (human 5-HT4).
PC-73306

ASP2205

5-HT2C agonist

ASP2205 (ASP2205 fumarate) is a potent, selective 5-HT2C receptor agonist with EC50 of 0.85/2.5 nM for human/rat 5-HT2C in the intracellular Ca2+ mobilization assays, respectively.
PC-73305

PZ-1361

5-HT7 antagonist

PZ-1361 is a potent and selective 5-HT7 receptor antagonist with Ki of 33 nM, exhibit significant in vivo antidepressant and pro-cognitive properties in rodents.
PC-73304

AGH-192

5-HT7 agonist

AGH-192 is a potent, selective, orally bioavailable 5-HT7 receptor agonist with Ki of 4 nM.
PC-73303

AGH-107

5-HT7 agonist

AGH-107 is a potent, selective 5-HT7 receptor agonist with Ki of 6 nM and EC50 of 19 nM, 176-fold selectivity over 5-HT1AR.
PC-73302

AVN-492

5-HT6 antagonist

AVN-492 is a highly potent and selective 5-HT6 receptor antagonist with Ki of 91 pM, >1000-fold selectivity over 5-HT2BR (Ki=170 nM).
PC-73301

ST1936 oxalate

5-HT6 agonist

ST1936 is a potent, selective 5-HT6 receptor agonist with Ki of 13 nM, >10-fold selectivity over 5-HT7 and 5-HT2B receptors.
PC-73300

LP-211

5-HT7 agonist

LP-211 is a potent, selective, and BBB-penetrant 5-HT7 receptor agonist with Ki of 0.58 nM, high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM).
PC-73299

Usmarapride

5-HT4 agonist

Usmarapride (SUVN-D4010) is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist with EC50of 44 nM.

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