| Cat. No. |
Product Name |
Information |
| PC-42653 |
Ketanserin
5-HT2A antagonist
|
Ketanserin (R41468) is a high-affinity, non-selective antagonist of 5-HT2 receptor with Ki of 2-3 nM for 5-HT2A and 28 nM for 5-HT2C. |
| PC-45229 |
Ziprasidone hydrochloride monohydrate
D2/5-HT2A antagonist
|
Ziprasidone hydrochloride monohydrate (CP-88059) is a full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively. |
| PC-43963 |
Ziprasidone
D2/5-HT2A antagonist
|
Ziprasidone (CP 88059) is a full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively. |
| PC-28313 |
IHCH-7179
5-HT1AR agonist, 5-HT2AR antagonist
|
IHCH-7179 is a potent dual-targeted 5-HT2AR antagonist and 5-HT1AR agonist, effectively alleviates psychoactive symptoms and cognitive deficits in mice. |
| PC-28311 |
IHCH-6122
5-HT2A agonist
|
IHCH-6122 is a potent agonist of serotonin 2A receptor (5-HT2AR) with Gq EC50 of 97.7 nM (Emax = 109%) and β-arrestin2 recruitment EC50 of 186 nM (Emax =73%), shows antagonist activity at 5-HT2BR, shows antidepressant effects. |
| PC-28310 |
IHCH-1906
5-HT2A agonist
|
IHCH-1906 is a potent agonist of serotonin 2A receptor (5-HT2AR) with Gq EC50 of 12.6 nM (Emax = 85%) and β-arrestin2 recruitment EC50 of 75.9 nM (Emax = 78%), shows antagonist activity at 5-HT2BR, partial agonist at 5-HT1DR (EC50 = 72.4 nM, Emax = 56%), and minimal activity at other receptors. |
| PC-28309 |
IHCH-6082
5-HT2A agonist
|
IHCH-6082 is a potent agonist of serotonin 2A receptor (5-HT2AR) with Gq EC50 of 871 nM (Emax = 98%) and β-arrestin2 recruitment EC50 of 813 nM (Emax =60%), shows antagonist activity at 5-HT2BR, shows rapid and lasting antidepressant effects. |
| PC-28308 |
IHCH-7086
5-HT2A agonist
|
IHCH-7086 is a potent, BBB-permeable, partial β-arrestin-biased agonist of serotonin 2A receptor (5-HT2AR) with Ki of 12.59 nM. |
| PC-28307 |
IHCH-7113
5-HT2A agonist
|
IHCH-7113 is a selective agonist of serotonin 2A receptor (5-HT2AR) with EC50 of 58.9 nM in Gq BRET assay and 44.7 nM in β-arrestin 2 BRET assays, activates both Gαq-mediated signaling pathways and β-arrestin 2 recruitment pathways and shows antidepressant activity. |
| PC-28229 |
(R)-α-methylhistamine
H3 receptor agonist
|
(R)-α-methylhistamine (RAMH, (R)-(-)-α-Methylhistamine) is a potent, selective and brain-penetrant agonist of H3 histamine receptor (H3R) with Kd of 50.3 nM, enhances memory retention and attenuates memory impairment in vivo. |
| PC-28213 |
Astemizole
H1 receptor antagonist, hERG blocker
|
Astemizole (R43512) is a second-generation histamine H1-receptor antagonist with IC50 of 4 nM, also shows potent hERG K+ channel blocking activity with IC50 of 0.9 nM. |
| PC-28212 |
Cisapride monohydrate
hERG blocker, 5-HT4 agonist
|
Cisapride monohydrate (R 51619) is a potent, selective and orally active 5-HT4 receptor agonist with EC50 of 140 nM, is also an hERG potassium channel blocker with IC50 of 9.4 nM, inhibits voltage-dependent K(+) (Kv) channels using freshly isolated smooth muscle cells. |
